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Comparison of the Working Formulation of non-Hodgkin’s lymphoma with the Rappaport, the Kiel, and the Lukes-Collins Classifications. Correlations and prognostic value

  • J. Ersbøll
  • H. B. Schultz
  • N. I. Nissen
  • P. Hougaard
  • K. Hou-Jensen
Chapter
  • 42 Downloads
Part of the Developments in Oncology book series (DION, volume 32)

Abstract

The Rappaport classification of non-Hodgkin’s lymphoma [1] gained universal acceptance as a valuable basic diagnostic language for communication of therapeutic results among medical centers in the period 1968–75. Recognition that non-Hodgkin’s lymphomas represent neoplasms of the lymphocytic immune system has resulted in new classifications based upon modern concepts of the T- and B-lymphocyte systems [2, 3]. Other newer classification schemes have challenged the terminology used by Rappaport [4–6], and the Rappaport system itself has been modified several times [7–9]. The existence and the use of many histologic classifications for the non-Hodgkin’s lymphomas prompted the United States National Cancer Institute to sponsor a large international multi-institutional clinicopathologic study comparing six classifications. The results were published in 1982, and two important conclusions were reached [10]: ‘First, each system is successful in separating a large group of patients into subgroups with a spectrum of prognoses varying from good to poor survival. Second, no system appears superior to any other in this respect’. Based on this study, the investigators reached consensus on a ‘Working Formulation of non-Hodgkin’s Lymphoma for Clinical Usage’.

Keywords

Malignant Lymphoma Working Formulation Lymphoma Entity Kiel Classification United States National Cancer Institute 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Martinus Nijhoff Publishers, Boston 1985

Authors and Affiliations

  • J. Ersbøll
    • 1
  • H. B. Schultz
    • 1
  • N. I. Nissen
    • 1
  • P. Hougaard
    • 1
  • K. Hou-Jensen
    • 1
  1. 1.The Finsen Institute, and Statistical Research UnitUniversity of CopenhagenDenmark

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