Comparison of the Working Formulation of non-Hodgkin’s lymphoma with the Rappaport, the Kiel, and the Lukes-Collins Classifications. Correlations and prognostic value
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The Rappaport classification of non-Hodgkin’s lymphoma  gained universal acceptance as a valuable basic diagnostic language for communication of therapeutic results among medical centers in the period 1968–75. Recognition that non-Hodgkin’s lymphomas represent neoplasms of the lymphocytic immune system has resulted in new classifications based upon modern concepts of the T- and B-lymphocyte systems [2, 3]. Other newer classification schemes have challenged the terminology used by Rappaport [4–6], and the Rappaport system itself has been modified several times [7–9]. The existence and the use of many histologic classifications for the non-Hodgkin’s lymphomas prompted the United States National Cancer Institute to sponsor a large international multi-institutional clinicopathologic study comparing six classifications. The results were published in 1982, and two important conclusions were reached : ‘First, each system is successful in separating a large group of patients into subgroups with a spectrum of prognoses varying from good to poor survival. Second, no system appears superior to any other in this respect’. Based on this study, the investigators reached consensus on a ‘Working Formulation of non-Hodgkin’s Lymphoma for Clinical Usage’.
KeywordsMalignant Lymphoma Working Formulation Lymphoma Entity Kiel Classification United States National Cancer Institute
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