Patterns of survival in advanced non-Hodgkin’s lymphoma
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In the development of clinical experience, certain factors come to be associated empirically with an extreme prognosis (for example, very long or very short survival). This clinical impression can be quantitated by examining the capacity such factors have to separate the patient population into two or more sub-groups each with a distinct and different survival experience. Those which univariately separate the sample population into statistically significant groupings rightfully assume a greater role in subsequent clinical thinking. Much clinical research has been devoted to comparing the survival experience of patient populations divided into subgroups by combinations of factors which make especially good clinical sense. Unfortunately, even the number of clinically sensible combinations is very large; and the testing of so multiple a hypothesis has its own pitfalls.
KeywordsFavorable Histology Unfavorable Histology Good Prognosis Patient Entropy Limited Karnofsky Status
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