The current status of the Stanford randomized clinical trials of the management of Hodgkin’s disease
- 42 Downloads
Randomized trials designed to improve the management of patients with Hodgkin’s disease were initiated at Stanford University in 1962. These studies tested different irradiation programs for patients with Clinical Stages (CS) I, II and III disease. In 1967 the study for patients with Stages IA and IIA was modified utilizing more extensive radiation fields and as of July 1968 routine diagnostic exploratory laparotomy and splenectomy.
KeywordsPathologic Stage Combine Modality Combine Modality Therapy Involve Field Irradiation Total Lymphoid Irradiation
Unable to display preview. Download preview PDF.
- 1.Rosenberg SA, Kaplan HS, Hoppe RT et al. (1982). The Stanford randomized trials of the treatment of Hodgkin’s disease: 1967–1980. In: Rosenberg SA and Kaplan HS (Eds.). Malignant Lymphomas: Etiology, Immunology, Pathology, Treatment, pp. 513–522. New York: Academic Press.Google Scholar
- 4.Cox DR (1972). Regression models and life tables. J Roy Stat Soc B 34: 187–220.Google Scholar
- 5.Kaplan HS (1980). Hodgkin’s Disease, 2nd ed. Cambridge, London: Harvard University Press.Google Scholar
- 6.DeVita VT Jr, Serpick AA and Carbone PP (1970). Combination chemotherapy in the treatment of advanced Hodgkin’s disease. Ann Intern Med 75: 881–895.Google Scholar
- 8.Wolin EM, Rosenberg SA and Kaplan HS (1979). A randomized comparison of PAVe and MOP(P) as adjuvant chemotherapy for Hodgkin’s disease. In: Salmon SE and Jones SE (Eds). Adjuvant Therapy of Cancer. II, pp. 119–127. New York: Grune and Stratton.Google Scholar
- 9.Santoro A, Bonfante V, Bonadonna G et al. (1981). Therapeutic and toxicologic effects of MOPP vs ABVD combined with radiotherapy in Hodgkin’s disease. In: Salmon SE and Jones SE (Eds). Adjuvant Therapy of Cancer. III., pp. 85–91. New York: Grune and Stratton.Google Scholar