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Treatment of early stage Hodgkin’s disease: A randomized trial of radiotherapy plus chemotherapy versus chemotherapy alone

  • P. J. O’Dwyer
  • P. H. Wiernik
  • M. B. Stewart
  • R. G. Slawson
Chapter
Part of the Developments in Oncology book series (DION, volume 32)

Abstract

In 1976, extended field megavoltage radiation had become standard therapy for Hodgkin’s disease confined to lymph nodes [1, 2]. While essentially all patients with Stage I disease are cured by this technique, it has become apparent that a significant number of patients with more advanced disease relapse after treatment with radiotherapy alone. This is especially true of Stage IIIA disease [3], and those with large mediastinal masses with or without extranodal extension into lung [4, 5], but among all Stages I and II, relapse rates as high as 27% have been reported [6]. The recognition that combination chemotherapy could prolong both duration of second remission and survival in patients relapsing after radiation therapy [6, 7], prompted the evaluation of several combined modality regimens as initial treatment in patients with Stages I to IIIA disease [8–12]. The apparent benefits of this approach in terms of remission duration [9], and the growing awareness of undesirable long-term toxic effects of combined modality therapy [13], prompted the present study. Interim analyses have been presented previously [14, 15].

Keywords

Infective Endocarditis Combine Modality Constrictive Pericarditis Combine Modality Therapy Remission Duration 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Martinus Nijhoff Publishers, Boston 1985

Authors and Affiliations

  • P. J. O’Dwyer
    • 1
  • P. H. Wiernik
    • 1
  • M. B. Stewart
    • 1
  • R. G. Slawson
    • 1
  1. 1.University of Maryland Cancer Center (formerly Baltimore Cancer Research Center)BaltimoreUSA

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