Surgical restaging after 3 or 6 courses of MOPP chemotherapy in Hodgkin’s disease

  • C. Ferme
  • F. Teillet
  • M. F. D’Agay
  • M. Boiron
Part of the Developments in Oncology book series (DION, volume 32)


A majority of patients with Hodgkin’s disease can achieve complete remission and recovery with radiotherapy, combination chemotherapy or both [1–4]. Risks associated with intensive treatments, including the possible occurrence of second malignancies, have led several investigators to evaluate less aggressive therapy. Pretreatment staging laparotomies are used to detect occult disease, especially in the spleen [5–7]. More recently, post-chemotherapy surgical restaging has been introduced to identify minimal residual disease and define further therapeutic strategies [8, 9].


Minimal Residual Disease Complete Remission Rate Clinical Complete Remission Surgical Response Extended Field Irradiation 
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  1. 1.
    DeVita VT, Simon RM, Hubbard SM et al. (1980). Curability of advanced Hodgkin’s disease with chemotherapy: Long-term follow up of MOPP treated patients at NCI. Ann Inter Med 92: 587–595.Google Scholar
  2. 2.
    Farber LR, Prosnitz LR, Cadman EC et al. (1980). Curative potential of combined modality therapy for advanced Hodgkin’s disease. Cancer 46: 1509–1517.PubMedCrossRefGoogle Scholar
  3. 3.
    Kaplan HS (1980). Hodgkin’s Disease, 2nd ed. Cambridge: Harvard University Press.Google Scholar
  4. 4.
    Santoro A, Bonadonna G, Bonfante V and Valagussa P (1982). Alternating drug combinations in the treatment of advanced Hodgkin’s disease. N Engl J Med 306: 770–775.PubMedCrossRefGoogle Scholar
  5. 5.
    Glatstein E, True-Blood HW, Enright LP et al. (1970). Surgical staging of abdominal involvement in unselected patients with Hodgkin’s disease. Radiology 97: 425–432.PubMedGoogle Scholar
  6. 6.
    Kaplan HS, Dorfman RF, Nelson TS et al. (1973). Staging laparotomy and splenectomy in Hodgkin’s disease: Analysis of indications and patterns of involvement in 285 consecutive unselected patients. Nat Cancer Inst Monograph 36: 291–301.Google Scholar
  7. 7.
    Aisenberg AC and Qasi R (1974). Abdominal involvement at the onset of Hodgkin’s disease. Amer J Med 57: 870–874.PubMedCrossRefGoogle Scholar
  8. 8.
    Goodman GE, Jones SE, Villar HV et al. (1982). Surgical restaging of Hodgkin’s disease. Cancer Treat Rep 66: 751–757.PubMedGoogle Scholar
  9. 9.
    Sutcliffe SB, Wrigley PFM, Timothy AR et al. (1982). Posttreatment laparotomy as a guide to management in patients with Hodgkin’s disease. Cancer Treat Rep 66: 759–765.PubMedGoogle Scholar

Copyright information

© Martinus Nijhoff Publishers, Boston 1985

Authors and Affiliations

  • C. Ferme
    • 1
  • F. Teillet
    • 2
  • M. F. D’Agay
    • 3
  • M. Boiron
    • 4
  1. 1.Département de Médecine Interne et OncologieC.M.C. de BlignyBruis sous ForgesFrance
  2. 2.Service d’Hématologie-ImmunologieHôpital Louis MourierColombesFrance
  3. 3.Service d’Anatomie PathologieFrance
  4. 4.Département Hémato-OncologieHôpital Saint-LouisParis, Cedex 10France

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