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Chemotherapy (MVPP) for Stage IIIB/IV Hodgkin’s disease with an assessment of prognostic factors

  • W. P. Steward
  • J. Wagstaff
  • I. D. Todd
  • D. Crowther
Chapter
  • 42 Downloads
Part of the Developments in Oncology book series (DION, volume 32)

Abstract

Of all patients presenting with Hodgkin’s disease, in excess of 30% will have Clinical Stage (CS) IIIB or IV disease or will be found to have Pathologic Stage (PS) IIIB/IV disease following staging laparotomy. Prior to the use of combination chemotherapy with mustine, vincristine, procarbazine and prednisolone (MOPP) [1], the prognosis for such patients was bleak. With the advent of the MOPP regimen a high percentage of durable complete remissions could be obtained. The dramatic improvement in survival for these patients has, however, led to a popular misconception that advanced stage Hodgkin’s Disease is a readily curable malignancy. Unfortunately, despite drug and dosage alterations, little advance has been made in the 20 years since the introduction of MOPP and 30–40% of patients will die using currently available therapy [2–4].

Keywords

Complete Remission Remission Status Durable Complete Remission Total Patient Group Curable Malignancy 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Martinus Nijhoff Publishers, Boston 1985

Authors and Affiliations

  • W. P. Steward
    • 1
  • J. Wagstaff
    • 1
  • I. D. Todd
    • 2
  • D. Crowther
    • 1
  1. 1.Departments of Medical OncologyChristie Hospital and Holt Radium InstituteManchesterUK
  2. 2.Departments of RadiotherapyChristie Hospital and Holt Radium InstituteManchesterUK

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