Banded chromosome abnormalities in non-Hodgkin’s lymphoma. Correlations with morphology, immunologic phenotype and clinical course
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Limited data are available regarding chromosomal abnormalities in malignant lymphoma, other than Burkitt’s. The few reported studies of banded chromosomes have generally been based on small series (less than 50 cases) and have often included many incomplete karyotypes. Bone marrow, blood or effusions have frequently been studied rather than lymph nodes or other primary tumor masses, and relatively few patients have been studied at diagnosis. Moreover, for a given lymph node, chromosome findings have rarely been correlated with histology and immunologic phenotype. Since July 1978, we have been prospectively studying chromosomal abnormalities in lymph nodes from patients with lymphoma and correlating them with histology, immunologic phenotype and clinical findings [1, 2]. In this manuscript we briefly review our findings in the first 115 patients.
KeywordsChromosome Abnormality Follicular Lymphoma Modal Number Human Cytogenetic Nomenclature Immunologic Phenotype
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