Chromosomal aberrations in leukemic low-grade malignant B-cell lymphoproliferative neoplasias

  • G. Gahrton
  • G. Juliusson
  • K. H. Robert
  • K. Friberg
  • L. Zech
Part of the Developments in Oncology book series (DION, volume 32)


The low-grade malignant B-cell lymphoproliferative disorders with leukemic cells in the peripheral blood (LMBLL) are practically all included in what is usually called chronic lymphocytic leukemia (CLL). When it became obvious that CLL was a heterogenous disease, it was subdivided in several groups, e.g. according to the Kiel classification [1]. New entities such as immunocytoma, prolymphocytic leukemia, and centrocytic lymphoma, were separated from CLL. Our original aim was to investigate the ‘classical’ CLL for possible presence of specific chromosomal aberrations. The study includes patients within the new subgroups, but only those who presented with a leukemic picture, i.e. a blood lymphocyte count of at least 5 × 109/1.


Chronic Lymphocytic Leukemia Chromosomal Aberration Chronic Lymphocytic Leukemia Patient Extra Chromosome Prolymphocytic Leukemia 
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Copyright information

© Martinus Nijhoff Publishers, Boston 1985

Authors and Affiliations

  • G. Gahrton
    • 1
  • G. Juliusson
    • 1
  • K. H. Robert
    • 1
  • K. Friberg
    • 1
  • L. Zech
    • 1
  1. 1.Division of Clinical Hematology and Oncology, Department of MedicineHuddinge Hospital and Karolinska Institute, and Institute of Medical Cell Genetics, Medical Nobel Institute, Karolinska InstituteStockholmSweden

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