The Mouse Oocyte Toxicity Assay

  • James S. Felton
  • R. Lowry Dobson
Part of the Environmental Science Research book series (ESRH, volume 27)


Certain chemicals, including energy-related pollutants such as polycyclic aromatic hydrocarbons (PAHs) are highly destructive to mouse female germ cells (Felton et al., 1980). Like ionizing radiation, these chemicals readily kill oocytes, and the gametic cell loss can be quantified to provide dose-response curves and in vivo measurements of chemical cytotoxicity.


Mouse Oocyte Relative Biological Effectiveness Lawrence Livermore National Laboratory Female Germ Cell Oocyte Survival 
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Copyright information

© Plenum Press, New York 1983

Authors and Affiliations

  • James S. Felton
    • 1
    • 2
  • R. Lowry Dobson
    • 1
    • 2
  1. 1.Biomedical Sciences DivisionLawrence Livermore National LaboratoryLivermoreUSA
  2. 2.University of CaliforniaLivermoreUSA

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