Recent Experience with the Strain a Mouse Pulmonary Tumor Bioassay Model
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Since its Inception in November 1978, a major mandate of the National Toxicology Program (NTP) has been to identify toxic chemicals that must be controlled to prevent human disease. A consequent goal of this mandate is to support the development of efficient and economical methods that will identify biological effects and carcinogenic potential of chemicals. The strain A mouse pulmonary tumor test system has long been considered a useful in vivo animal model to predict potential carcinogenicity of chemicals (Shimkin and Stoner, 1975). This report communicates some recent experiences with the strain A mouse test system derived from separate contributions from two laboratories supported by the NTP.
KeywordsMaximum Tolerate Dose Aromatic Amine Pulmonary Tumor National Toxicology Program Direct Blue
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