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Recent Experience with the Strain a Mouse Pulmonary Tumor Bioassay Model

  • R. R. Maronpot
  • H. P. Witschi
  • L. H. Smith
  • J. L. McCoy
Chapter
Part of the Environmental Science Research book series (ESRH, volume 27)

Abstract

Since its Inception in November 1978, a major mandate of the National Toxicology Program (NTP) has been to identify toxic chemicals that must be controlled to prevent human disease. A consequent goal of this mandate is to support the development of efficient and economical methods that will identify biological effects and carcinogenic potential of chemicals. The strain A mouse pulmonary tumor test system has long been considered a useful in vivo animal model to predict potential carcinogenicity of chemicals (Shimkin and Stoner, 1975). This report communicates some recent experiences with the strain A mouse test system derived from separate contributions from two laboratories supported by the NTP.

Keywords

Maximum Tolerate Dose Aromatic Amine Pulmonary Tumor National Toxicology Program Direct Blue 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. Shimkin, M.B. and G.D. Stoner. 1975. Lung tumors in mice: application to carcinogenesis bioassay. Adv. Cancer Res. 21:1–58.CrossRefGoogle Scholar

Copyright information

© Plenum Press, New York 1983

Authors and Affiliations

  • R. R. Maronpot
    • 1
  • H. P. Witschi
    • 2
  • L. H. Smith
    • 2
  • J. L. McCoy
    • 1
  1. 1.National Toxicology ProgramResearch Triangle ParkUSA
  2. 2.Oak Ridge National LaboratoryOak RidgeUSA

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