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Biological Activity of Air Particulate Extracts (APE) in Short-Term Test

  • Hélène M. Coulomb
  • Yves A. Courtois
  • Françoise Boizard Callais
  • Bernard Festy
  • Ivan Chouroulinkov
Chapter
Part of the Environmental Science Research book series (ESRH, volume 27)

Abstract

Due to the increase of lung cancer incidence in developed countries (Higgins, 1976; Higginson, 1976, 1979), systematic controls of air quality, physicochemical and biological characterizations, are recommended. With the recent progress in technology, the physicochemical characterization of air pollution is, in our opinion, relatively easy to realize. In contrast, the methodology to evaluate the carcinogenic and mutagenic potentials of complex mixtures still requires improvement. For these investigations, short-term tests have been useful. The Salmonella/microsome mutagenicity test (developed by Ames et al.) has been shown to be especially effective in evaluating the mutagenic activity of air particulate extracts (Tokiwa et al., 1977; Talcott and Wei, 1977; Commoner et al., 1978; Teranishi et al., 1978; Coviaux et al., 1980). Nevertheless, for a better evaluation of carcinogenic potential, one mutagenicity test is not sufficient; a battery of tests is better and more suitable.

Keywords

Sister Chromatid Exchange Cloning Efficiency Lung Cancer Incidence Cigarette Smoke Condensate Hamster Embryo Cell 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Plenum Press, New York 1983

Authors and Affiliations

  • Hélène M. Coulomb
    • 1
  • Yves A. Courtois
    • 2
  • Françoise Boizard Callais
    • 3
  • Bernard Festy
    • 3
  • Ivan Chouroulinkov
    • 1
  1. 1.Institut de Recherches Scientifiques sur le CancerVille juifFrance
  2. 2.Laboratoire d’Hygiène de la Ville de ParisFrance
  3. 3.Université Paris VFrance

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