Application of Mutagenicity Tests for Detection and Source Assessment of Genotoxic Agents in the Rubber Work Atmosphere

  • Agneta Hedenstedt Rannug
  • Conny Östman
Part of the Environmental Science Research book series (ESRH, volume 27)


In 1954, the increased risks of developing urinary bladder tumors were established among rubber workers (Case and Hosker, 1954). Later, other cancer forms were reported to appear in excess among workers in this industry (Peters et al., 1976; Monson and Fine, 1978; Hakama and Kilpikari, in press). The earlier use of beta-naphthylamine as an antioxidant was probably the single cause of the bladder tumors. Dust has been suggested as the most probable cause of stomach cancer among workers in the weighing and mixing departments (Maisey, 1981). Exposure to hazardous substances in fumes generated during the vulcanization of rubber leads to an elevated risk of developing lung disease (Peters et al., 1976; Maisey, 1981). This exposure may also explain the enhanced lung cancer frequencies found among workers in the curing department (Fox et al., 1974).


Natural Rubber Mutagenicity Test Rubber Material Styrene Butadiene Rubber Genotoxic Agent 
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Copyright information

© Plenum Press, New York 1983

Authors and Affiliations

  • Agneta Hedenstedt Rannug
    • 1
  • Conny Östman
    • 2
  1. 1.Department of Toxicology Genetics, Wallenberg LaboratoryUniversity of StockhomStockholmSweden
  2. 2.Department of Analytical Chemistry, Arrhenius LaboratoryUniversity of StockholmStockholmSweden

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