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Activity of the Salvage-Pathway in Erythrocytes of Newborn Infants, Children and Adults

  • M. M. Müller
  • P. Wagenbichler
Chapter
  • 95 Downloads
Part of the Advances in Experimental Medicine and Biology book series

Abstract

Since the important investigations from WILLIAMS (20) and GOLDWATER (4) in 1953 it is well known that besides the de novo synthesis of purines there exists a one-step reaction for the formation of purine nucleotides from purine bases. In this salvage-pathway (Figure 1) phosphoribosylpyrophosphate (PP-ribose-P, PRPP), which is catalyzed by phosphoribosylpyrophosphate synthetase (PP-ribose-P synthetase, PRPP-synthetase, E.C. 2.7.6.1) from ribose-5-phosphate and ATP, acts as ribose-5-phosphate donator. Cells of mammals contain two different enzymes for this synthesis of purine nucleotides from bases: the adenine phosphoribosyltransferase (APRT, E.C. 2.4.2.7), which catalyzes the formation of adenosinemonophosphate (AMP) from adenine and the hypoxanthine-guanine phosphoribosyltransferase (HGPRT, E.C. 2.4.2.8) converting hypoxanthine, guanine and xanthine to their nucleotides.

Keywords

Newborn Infant Pyruvate Kinase Adenylate Kinase Purine Nucleotide Purine Base 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Plenum Press, New York 1977

Authors and Affiliations

  • M. M. Müller
    • 1
  • P. Wagenbichler
    • 1
  1. 1.1st Department of Medical Chemistry and 1st Department of GynaecologyUniversity of ViennaAustria

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