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Fibroblast Phosphoribosylpyrophosphate and Ribose-5-Phosphate Concentration and Generation in Gout with Purine Overproduction

  • Michael A. Becker
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Part of the Advances in Experimental Medicine and Biology book series

Abstract

Despite the identification of several hereditary enzyme abnormalities which result in excessive uric acid synthesis (1–4), the underlying metabolic defects in the great majority of individuals with gout and purine overproduction have not been defined by routine screening of enzyme activities (5,6). For this reason, a different approach to the identification of additional enzyme abnormalities or of subtle variants of known enzyme abnormalities has been developed (7). This approach is based on our present understanding of the regulation of the rate of purine synthesis de novo schematically summarized in Figure 1.

Keywords

Uric Acid Purine Nucleotide Erythrocyte Lysate Purine Synthesis Uric Acid Excretion 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Abbreviations

HGPRT

hypoxanthine-guanine phosphoribosyltransferase

PP-ribose-P

5-phosphoribosyl 1-pyrophosphate

PAT

PP-ribose-P amidotransferase

PRT

phosphoribosyltransferase

FGAR

formylglycinamide ribotide

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References

  1. 1.
    Seegmiller, J. E., Rosenbloom, F. M. and Kelley, W. N.: Soienee (Wash, D.C.) 155: 1682–1684 (1967).CrossRefGoogle Scholar
  2. 2.
    Alepa, F. P., Howell, R. R., Klinenberg, J. R. and Seegmiller, J. E.: Am. J. Med. 42: 58–66 (1967).PubMedCrossRefGoogle Scholar
  3. 3.
    Kelley, W. N., Rosenbloom, F. M., Henderson, J. F. and Seegmiller, J. E.: Proc. Natl. Acad. Sci. U.S.A. 57: 1735–1739 (1967).PubMedCrossRefGoogle Scholar
  4. 4.
    Sperling, O., Boer, P., Persky-Brosh, S., Kanarek, E. and De Vries, A.: Rev. Eur. Etud. Clin. Biol. 17: 703–706 (1972).PubMedGoogle Scholar
  5. 5.
    Yu, T.-F., Balis, M. E., Krenitsky, T. A., Dancis, J., Silvers, D. N., Elion, G. B. and Gutman, A. B.: Ann. Intern. Med. 76: 255–265 (1972).PubMedGoogle Scholar
  6. 6.
    Becker, M. A. and Seegmiller, J. E.: Annu. Rev. Med. 25: 15–28 (1974).PubMedCrossRefGoogle Scholar
  7. 7.
    Becker, M. A.: J. Clin. Invest. 57: 308–318 (1976).PubMedCrossRefGoogle Scholar
  8. 8.
    Becker, M. A., Meyer, L. J. and Seegmiller, J. E.: Am. J. Med. 55: 232–242 (1973).PubMedCrossRefGoogle Scholar
  9. 9.
    Holmes, E. W., McDonald, J. A., McCord, J. M., Wyngaarden, J. B. and Kelley, W. N.: J. Biol. Chem. 248: 144–150 (1973).PubMedGoogle Scholar
  10. 10.
    Holmes, E. W., Wyngaarden, J. B. and Kelley, W. N.: J. Biol. Chem. 248: 6035–6040 (1973).PubMedGoogle Scholar
  11. 11.
    Rosenbloom, F. M., Henderson, J. F., Caldwell, I. C., Kelley, W. N. and Seegmiller, J. E.: J. Biol. Chem. 243: 1166–1173 (1968).PubMedGoogle Scholar
  12. 12.
    Henderson, J. F., Rosenbloom, F. M., Kelley, W. N. and Seegmiller, J. E.: J. Clin. Invest. 47: 1511–1516 (1968).PubMedCrossRefGoogle Scholar
  13. 13.
    Seegmiller, J. E., Grayzel, A. I., Laster, L. and Liddle, L.: J. Clin. Invest. 40: 1304–1314 (1961).PubMedCrossRefGoogle Scholar
  14. 14.
    Martin, D. W., Jr., Graf, L. H., Jr., McRoberts, J. A. and Harrison, T. M.: Clin. Res. 23: 263a (1975).Google Scholar
  15. 15.
    Reem, G. H.: Science (Wash., D.C.) 170: 1098–1099 (1975).CrossRefGoogle Scholar
  16. 16.
    Henderson, J. F.: J. Biol. Chem. 237: 2631–2635 (1962).PubMedGoogle Scholar
  17. 17.
    Boyle, J. A., Raivio, K. O., Becker, M. A. and Seegmiller, J. E.: Biochim. Biophys. Acta 269: 179–183 (1972).PubMedCrossRefGoogle Scholar
  18. 18.
    Fox, I. H. and Kelley, W. N.: Ann. Intern. Med. 74: 424–433 (1971).PubMedGoogle Scholar
  19. 19.
    Greene, M. L. and Seegmiller, J. E.: J. Clin. Invest. 48: 32a (1971).Google Scholar
  20. 20.
    Sperling, O., Eilam, G., Persky-Brosh, S. and De Vries, A.: J. Lab. Clin. Med. 79: 1021–1026 (1972).PubMedGoogle Scholar

Copyright information

© Plenum Press, New York 1977

Authors and Affiliations

  • Michael A. Becker
    • 1
    • 2
  1. 1.Department of MedicineUniversity of California, San DiegoLa JollaUSA
  2. 2.San Diego Veterans Administration HospitalLa JollaUSA

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