Fibroblast Phosphoribosylpyrophosphate and Ribose-5-Phosphate Concentration and Generation in Gout with Purine Overproduction

  • Michael A. Becker
Part of the Advances in Experimental Medicine and Biology book series


Despite the identification of several hereditary enzyme abnormalities which result in excessive uric acid synthesis (1–4), the underlying metabolic defects in the great majority of individuals with gout and purine overproduction have not been defined by routine screening of enzyme activities (5,6). For this reason, a different approach to the identification of additional enzyme abnormalities or of subtle variants of known enzyme abnormalities has been developed (7). This approach is based on our present understanding of the regulation of the rate of purine synthesis de novo schematically summarized in Figure 1.


Uric Acid Purine Nucleotide Erythrocyte Lysate Purine Synthesis Uric Acid Excretion 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.



hypoxanthine-guanine phosphoribosyltransferase


5-phosphoribosyl 1-pyrophosphate


PP-ribose-P amidotransferase




formylglycinamide ribotide


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Copyright information

© Plenum Press, New York 1977

Authors and Affiliations

  • Michael A. Becker
    • 1
    • 2
  1. 1.Department of MedicineUniversity of California, San DiegoLa JollaUSA
  2. 2.San Diego Veterans Administration HospitalLa JollaUSA

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