An Alternate Metabolic Route for the Synthesis of Inosine 5′-Phosphate (IMP) in the Lesch-Nyhan Erythrocyte

  • Bertram A. Lowy
  • Marjorie K. Williams
Part of the Advances in Experimental Medicine and Biology book series


The cells of the Lesch-Nyhan individual, which are deficient in hypoxanthine-guanine phosphoribosyltransferase (HGPRT) activity, lack the ability to convert the 6-keto purines, hypoxanthine and guanine, to the corresponding nucleotides (1). Mammalian cells, in general, lack appreciable kinase activity for the 6-keto purine nucleosides, inosine and guanosine (2,3). Thus, the major route to IMP and GMP in the Lesch- Nyhan cell is via the overall pathway of de novo purine nucleotide synthesis in which the purine ring of IMP is built up on carbon 1 of a molecule of ribose 5-phosphate (4), The IMP is readily converted to GMP in normal human and Lesch-Nyhan cells.


Sodium Formate Adenine Phosphoribosyltransferase Washed Erythrocyte Tetrahydrofolic Acid Normal Adult Male 
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Copyright information

© Plenum Press, New York 1977

Authors and Affiliations

  • Bertram A. Lowy
    • 1
  • Marjorie K. Williams
    • 1
  1. 1.Department of BiochemistryAlbert Einstein College of MedicineBronxUSA

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