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An Alternate Metabolic Route for the Synthesis of Inosine 5′-Phosphate (IMP) in the Lesch-Nyhan Erythrocyte

  • Bertram A. Lowy
  • Marjorie K. Williams
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Part of the Advances in Experimental Medicine and Biology book series

Abstract

The cells of the Lesch-Nyhan individual, which are deficient in hypoxanthine-guanine phosphoribosyltransferase (HGPRT) activity, lack the ability to convert the 6-keto purines, hypoxanthine and guanine, to the corresponding nucleotides (1). Mammalian cells, in general, lack appreciable kinase activity for the 6-keto purine nucleosides, inosine and guanosine (2,3). Thus, the major route to IMP and GMP in the Lesch- Nyhan cell is via the overall pathway of de novo purine nucleotide synthesis in which the purine ring of IMP is built up on carbon 1 of a molecule of ribose 5-phosphate (4), The IMP is readily converted to GMP in normal human and Lesch-Nyhan cells.

Keywords

Sodium Formate Adenine Phosphoribosyltransferase Washed Erythrocyte Tetrahydrofolic Acid Normal Adult Male 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Plenum Press, New York 1977

Authors and Affiliations

  • Bertram A. Lowy
    • 1
  • Marjorie K. Williams
    • 1
  1. 1.Department of BiochemistryAlbert Einstein College of MedicineBronxUSA

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