Effect of Triiodothyronine on the Biosynthesis of Adenine Nucleotides and Proteins in the Rat Heart
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During the development of cardiac hypertrophy de novo synthesis of myocardial adenine nucleotides (AN) was found to be enhanced prior to the increase of protein synthesis (10, 11, 13, 14). However, there are differences concerning time course, direction and extent of changes of AN and protein synthesis in various experimental models of myocardial hypertrophy. After aortic constriction, AN synthesis was reduced within the first 5 hours, increased after 24 hours and reached a maximum on the third day (11). Protein synthesis showed a similar biphasic pattern with a reduction during the first 5 hours and an enhancement on the second day (10). In contrast, during development of cardiac hypertrophy induced by a single high dose of isoproterenol, both AN and protein synthesis were stimulated considerably already within the first 12 hours (13, 14).
KeywordsProtein Synthesis Cardiac Hypertrophy Adenine Nucleotide Heart Weight Aortic Constriction
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- 14).Zimmer, H.-G. and Gerlach, E.: Comparative studies of myocardial adenine nucleotide and protein synthesis in two models of cardiac hypertrophy. International Symposium of the International Study Group for Research in Cardiac Metabolism. Brussels, p. 75 1975.Google Scholar