Effect of Triiodothyronine on the Biosynthesis of Adenine Nucleotides and Proteins in the Rat Heart

  • H.-G. Zimmer
  • G. Steinkopff
  • E. Gerlach
Part of the Advances in Experimental Medicine and Biology book series


During the development of cardiac hypertrophy de novo synthesis of myocardial adenine nucleotides (AN) was found to be enhanced prior to the increase of protein synthesis (10, 11, 13, 14). However, there are differences concerning time course, direction and extent of changes of AN and protein synthesis in various experimental models of myocardial hypertrophy. After aortic constriction, AN synthesis was reduced within the first 5 hours, increased after 24 hours and reached a maximum on the third day (11). Protein synthesis showed a similar biphasic pattern with a reduction during the first 5 hours and an enhancement on the second day (10). In contrast, during development of cardiac hypertrophy induced by a single high dose of isoproterenol, both AN and protein synthesis were stimulated considerably already within the first 12 hours (13, 14).


Protein Synthesis Cardiac Hypertrophy Adenine Nucleotide Heart Weight Aortic Constriction 
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  1. 1).
    Gerlach, E., Deuticke, B., Dreisbach, R.H. and Rosarius, C.W.: Zum Verhalten von Nucleotiden und ihren dephosphorylierten Abbauprodukten in der Niere bei Ischämie und kurzzeitiger postischämischer Wiederdurchblutung. Pflügers Arch. 278, 296–315, 1963.CrossRefGoogle Scholar
  2. 2).
    Gudbjarnason, S., Telerman, M. and Bing, R.J.: Protein metabolism in cardiac hypertrophy and heart failure. Am. J. Physiol. 206, 294–298, 1964.PubMedGoogle Scholar
  3. 3).
    Koide, T., Rabinowitz, M.: Biochemical correlates of cardiac hypertrophy. II. Increased rate of RNA synthesis in experimental cardiac hypertrophy in the rat. Circulation Res. 24. 9–18, 1969.PubMedCrossRefGoogle Scholar
  4. 4).
    Meerson, F.Z.: Possible mechanism of cardiac hypertrophy. Acta biol. med. germ. 29, 271–280, 1972PubMedGoogle Scholar
  5. 5).
    Meerson, F.Z. and Pomoinitski, V.D.: The role of high-energy phosphate compounds in the development of cardiac hypertrophy. J. Mol. Cell. Cardiol. 4, 571–597, 1972PubMedCrossRefGoogle Scholar
  6. 6).
    Morkin, E., Kimata, S. and Skillman, J.J.: Myosin synthesis and degradation during development of cardiac hypertrophy in the rabbit. Circulation Res. 30, 690–702, 1972.PubMedCrossRefGoogle Scholar
  7. 7).
    Moroz, L.A.: Protein synthetic activity of heart microsomes and ribosomes during left ventricular hypertrophy in rabbits. Circulation Res. 21, 449–459, 1967.PubMedCrossRefGoogle Scholar
  8. 8).
    Nair, K.G., Cutiletta, A.F., Zak, R., Koide, T. and Rabinowitz, M.: Biochemical correlates of cardiac hypertrophy. I. Experimental model;changes in heart weight, RNA content, and nuclear RNA polymerase activity. Circulation Res. 23, 451–462, 1968.PubMedCrossRefGoogle Scholar
  9. 9).
    Rabinowitz, M. and Zak, R.: Biochemical and cellular changes in cardiac hypertrophy. Ann. Rev. Med. 23, 245–262, 1972.PubMedCrossRefGoogle Scholar
  10. 10).
    Zimmer, H.-G., Steinkopff, G. and Gerlach, E.: Changes of protein synthesis in the hypertrophying rat heart. Pflügers Arch. 336, 311–325, 1972.PubMedCrossRefGoogle Scholar
  11. 11).
    Zimmer, H.-G., Trendelenburg, Chr. and Gerlach, E.: Acceleration of adenine nucleotide synthesis de novo during development of cardiac hypertrophy. J. Mol. Cell. Cardiol. 4, 279–282, 1972.PubMedCrossRefGoogle Scholar
  12. 12).
    Zimmer, H.-G., Trendelenburg, Chr., Kammermeier, H. and Gerlach, E.: De novo synthesis of myocardial adenine nucleotides in the rat: Acceleration during recovery from oxygen deficiency. Circulation Res. 32, 635–642, 1973.PubMedCrossRefGoogle Scholar
  13. 13).
    Zimmer, H.-G. and Gerlach, E.: Effect of beta-adrenergic stimulation on myocardial adenine nucleotide metabolism. Circulation Res. 35, 536–543, 1974.PubMedCrossRefGoogle Scholar
  14. 14).
    Zimmer, H.-G. and Gerlach, E.: Comparative studies of myocardial adenine nucleotide and protein synthesis in two models of cardiac hypertrophy. International Symposium of the International Study Group for Research in Cardiac Metabolism. Brussels, p. 75 1975.Google Scholar

Copyright information

© Plenum Press, New York 1977

Authors and Affiliations

  • H.-G. Zimmer
    • 1
  • G. Steinkopff
    • 1
  • E. Gerlach
    • 1
  1. 1.Physiologisches InstitutUniversität MünchenMünchen 2Germany

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