Altered Synthesis and Catabolism of Purine Nucleotides in Regulatory Mutants of Saccharomyces Cerevisiae
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In 1970 Armitt and Woods (1) reported the isolation of a series of mutants of Saccharomyces cerevisiae that did not require purines for growth but which excreted substantial amounts of purines into the growth medium. Genetic studies showed that these yeast strains were associated with six unlinked genes (pur1, pur2, pur3, pur4, pur5, pur6), and although most of the mutations were recessive, one, pur6, had both recessive and dominant (PUR6) alleles.
KeywordsYeast Strain Purine Metabolism Purine Nucleotide Purine Base Nucleotide Synthesis
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