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Altered Synthesis and Catabolism of Purine Nucleotides in Regulatory Mutants of Saccharomyces Cerevisiae

  • J. Frank Henderson
  • P. W. Burridge
  • R. A. Woods
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Part of the Advances in Experimental Medicine and Biology book series

Abstract

In 1970 Armitt and Woods (1) reported the isolation of a series of mutants of Saccharomyces cerevisiae that did not require purines for growth but which excreted substantial amounts of purines into the growth medium. Genetic studies showed that these yeast strains were associated with six unlinked genes (pur1, pur2, pur3, pur4, pur5, pur6), and although most of the mutations were recessive, one, pur6, had both recessive and dominant (PUR6) alleles.

Keywords

Yeast Strain Purine Metabolism Purine Nucleotide Purine Base Nucleotide Synthesis 
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References

  1. 1.
    Armitt, S. and Woods, R. A. (1970) Genet. Res., 15, 7–17.PubMedCrossRefGoogle Scholar
  2. 2.
    Lomax, C. A., Bagnara, A. S. and Henderson, J. F. (1975) Can. J. Biochem., 53, 231–241.PubMedCrossRefGoogle Scholar
  3. 3.
    Warnick, C. T. and Paterson, A. R. P. (1973) Cancer Res., 33, 1711–1715.PubMedGoogle Scholar
  4. 4.
    Henderson, J. F., Brox, L. W., Kelley, W. N., Rosenbloom, F, M. and Seegmiller, J. E. (1968) J. Biol. Chem., 243, 2514–2522.PubMedGoogle Scholar
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    Henderson, J. F., Gadd, R. E. A., Palser, H. M. and Hori, M. (1970) Can. J. Biochem., 48, 573–579.PubMedCrossRefGoogle Scholar

Copyright information

© Plenum Press, New York 1977

Authors and Affiliations

  • J. Frank Henderson
    • 1
  • P. W. Burridge
    • 1
  • R. A. Woods
    • 1
  1. 1.Cancer Research Unit and Department of BiochemistryUniversity of AlbertaEdmontonCanada

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