Chemoprevention of Colon Cancer

  • Mary Mulcahy
  • Al BensonIII
Part of the Cancer Treatment and Research book series (CTAR, volume 106)


Adenocarcinoma of the large bowel presents a major public health problem. It affects about 1 person in 20 in the United States and Western countries [1]. It is the second most common cause of cancer death in American males, and the third most common cause in American females. When diagnosed and treated in its early stages, it is a highly curable disease. However, only half of all patients who present with colorectal cancer are cured by primary resection [2]. Primary prevention through the identification and eradication of risk factors responsible for the development of colorectal cancer is an area of active research throughout the world. Both environmental and genetic factors have been causally related to the development of colorectal cancer. Secondary prevention, by identifying premalignant lesions through screening techniques such as endoscopy, fecal occult blood testing, air-contrast barium enema, and CT colonography may potentially lead to a dramatic reduction in mortality. As a result of our improved understanding of the pathogenesis of colorectal cancer, the role of chemoprevention, either as primary or secondary prevention, and the targets for prevention, have been more readily defined.


Colorectal Cancer Colon Cancer Bile Acid Familial Adenomatous Polyposis Adenomatous Polyposis Coli 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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© Springer Science+Business Media New York 2001

Authors and Affiliations

  • Mary Mulcahy
  • Al BensonIII

There are no affiliations available

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