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Chemoprevention in Head and Neck Cancer

  • Ann Mellott
  • Everett Vokes
Chapter
Part of the Cancer Treatment and Research book series (CTAR, volume 106)

Abstract

Approximately 40,000 new cases of squamous cell carcinomas of the head and neck are diagnosed each year in the United States1. These oral, pharyngeal, laryngeal and sinus cancers represent about 5% of total cancer incidence. The majority of these patients present with disease confined to the head and neck region, with distant metastases occurring in less then 5% of patients at diagnosis. Traditionally surgery and radiation have been the modalities used to treat these cancers. Though the majority of AJC stage I and stageIIpatients may be cured with surgery and/or radiation therapy, less then 40% of patients with AJC stageIIIand IV are cured with this approach. More recently, clinical trials studying the combined approach of chemotherapy and radiation have reported 3-year survival rates in excess of 50%.2As the long-term prognosis of these advanced stage patients improves, and combination therapies become more standard, these patients are faced with significant risk of other cancers.

Keywords

Neck Cancer Cancer Chemoprevention Field Cancerization Oral Leukoplakia Betel Quid 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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© Springer Science+Business Media New York 2001

Authors and Affiliations

  • Ann Mellott
  • Everett Vokes

There are no affiliations available

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