Spoilage mechanisms

  • H. Lockhart
  • F. A. Paine


Whether they originate from chemical or biological sources, drugs and medicinal preparations can deteriorate and thus their therapeutic value can be reduced or destroyed. Chemical incompatibility between the ingredients of the medicine or with its packaging materials, as well as the effects of moisture, oxygen, light and temperature changes are the principal causes of such deterioration. Some of these effects may be prevented by suitable formulation of the medicament or its processing and are the province of the pharmaceutical chemist, as part of the product development process. In this chapter, however, the adverse effects that can be reduced or prevented by suitable packaging [1, 2, 3] are examined.


Packaging Material Product Development Process Cellulose Film Healthcare Product Climatic Hazard 
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Copyright information

© Springer Science+Business Media Dordrecht 1996

Authors and Affiliations

  • H. Lockhart
    • 1
    • 2
    • 3
  • F. A. Paine
    • 4
    • 5
  1. 1.School of PackagingMichigan State UniversityUSA
  2. 2.Center for Food Pharmaceutical ResearchUSA
  3. 3.Committee of RevisionU.S. Pharmacopeial ConventionUSA
  4. 4.School of PackagingMichigan State UniversityUSA
  5. 5.Packaging Technology & ManagementUSA

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