Absence of Prostaglandin E2-Induced Radioprotection in Two Cell Lines Lacking Specific PGE2-Binding Sites
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Prostaglandin E2 (PGE2) is an effective radioprotective agent in vivo but is not consistently radioprotective in vitro. The present study examines the possibility that PGE2-induced radioprotection is receptor mediated, and therefore, that cell lines lacking PGE2 receptors will not be protected. Two cell lines were examined: the DC3 transformed rat granulosa cell line which responds to PGE2 and the HSDM1C1 mouse fibrosarcoma cell line which produces PGE2.
KeywordsLuteal Cell PGE2 Receptor PGE2 Treatment Radiation Survival Chinese Hamster Lung Fibroblast
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