The Transfer RNAs of the Irradiated Mouse Spleen Contain Queuine
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The post transcriptional modification of tRNA whereby a guanine residue in the first position of the anticodon of certain tRNAs is excised and replaced by queuine occurs to a lesser extent in rapidly dividing cells than in quiescent cells. In this report we show that in the sub-lethally irradiated mouse even though the spleen increased seven fold in weight during the post-irradiation period of recovery there was only a slight increase in the (q-) tRNA. In dogs the bone marrow tRNAHis is completely (q-) however, the spleen tRNA is virtually 100% (q+). These results suggest that the presence of queuine has special importance in the metabolism of the spleen.
KeywordsLiver Kidney Microsomal Cytochrome Transfer RNAs Hematopoietic Organ Conventional Mouse
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