The Transfer RNAs of the Irradiated Mouse Spleen Contain Queuine

  • W. R. Farkas
  • L. Szabo
  • T. L. WaldenJr.
Part of the Developments in Oncology book series (DION, volume 67)


The post transcriptional modification of tRNA whereby a guanine residue in the first position of the anticodon of certain tRNAs is excised and replaced by queuine occurs to a lesser extent in rapidly dividing cells than in quiescent cells. In this report we show that in the sub-lethally irradiated mouse even though the spleen increased seven fold in weight during the post-irradiation period of recovery there was only a slight increase in the (q-) tRNA. In dogs the bone marrow tRNAHis is completely (q-) however, the spleen tRNA is virtually 100% (q+). These results suggest that the presence of queuine has special importance in the metabolism of the spleen.


Liver Kidney Microsomal Cytochrome Transfer RNAs Hematopoietic Organ Conventional Mouse 
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Copyright information

© Springer Science+Business Media New York 1991

Authors and Affiliations

  • W. R. Farkas
    • 1
  • L. Szabo
    • 1
  • T. L. WaldenJr.
    • 2
  1. 1.The University of Tennessee College of Veterinary MedicineKnoxvilleUSA
  2. 2.The Armed Forces Radiation Biology Research InstituteBethesdaUSA

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