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The Transfer RNAs of the Irradiated Mouse Spleen Contain Queuine

  • W. R. Farkas
  • L. Szabo
  • T. L. WaldenJr.
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Part of the Developments in Oncology book series (DION, volume 67)

Abstract

The post transcriptional modification of tRNA whereby a guanine residue in the first position of the anticodon of certain tRNAs is excised and replaced by queuine occurs to a lesser extent in rapidly dividing cells than in quiescent cells. In this report we show that in the sub-lethally irradiated mouse even though the spleen increased seven fold in weight during the post-irradiation period of recovery there was only a slight increase in the (q-) tRNA. In dogs the bone marrow tRNAHis is completely (q-) however, the spleen tRNA is virtually 100% (q+). These results suggest that the presence of queuine has special importance in the metabolism of the spleen.

Keywords

Liver Kidney Microsomal Cytochrome Transfer RNAs Hematopoietic Organ Conventional Mouse 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer Science+Business Media New York 1991

Authors and Affiliations

  • W. R. Farkas
    • 1
  • L. Szabo
    • 1
  • T. L. WaldenJr.
    • 2
  1. 1.The University of Tennessee College of Veterinary MedicineKnoxvilleUSA
  2. 2.The Armed Forces Radiation Biology Research InstituteBethesdaUSA

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