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Lipoxin Formation during Neutrophil-Platelet Interactions: a Role for Leukotriene A4 and Platelet 12-Lipoxygenase

  • C. N. Serhan
  • S. Fiore
  • K.-A. Sheppard
Chapter
  • 56 Downloads
Part of the Developments in Oncology book series (DION, volume 67)

Abstract

The lipoxins are a series of biologically active eicosanoids which contain a conjugated tetraene structure as a characteristic feature (1). The two main compounds which carry biological activities are positional isomers: one designated lipoxin A4 (5S,6R,15S-trihydroxy-7,9,13-trans-11-cis-eicosatetraenoic acid) and the other lipoxin B4 (5S,14R,15S, trihydroxy-6,10,12-trans-8-cis-eicosatetraenoic acid). Multiple pathways have been documented in vitro which can lead to the formation of lipoxins (1–4). It appears that the biosynthetic pathways utilized are species-, cell type- and substratespecific. One route, documented with results from both isotopic oxygen studies as well as the identification of alcohol trapping products, involves the transformation of 15-HETE to a 5(6)epoxytetraene by leukocytes (1). When this intermediate (15S-hydroxy-5,6-epoxy-7,9,13-trans-11-ciseicosatetraenoic acid) was synthesized and incubated with purified cytosolic epoxide hydrolase, it was quantitatively converted into LXA4 (5). During the formation of lipoxins from exogenous 15-HETE by human neutrophils (an event which may occur in cell-cell interactions), an inverse relationship is observed between leukotriene and lipoxin production (6). Thus, the generation of epoxide-containing intermediates by human PMN appears to play a pivotal role in the biosynthesis of both leukotrienes and lipoxins.

Keywords

Positional Isomer Eicosatetraenoic Acid Isotopic Oxygen Study Active Eicosanoid Cytosolic Epoxide Hydrolase 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer Science+Business Media New York 1991

Authors and Affiliations

  • C. N. Serhan
    • 1
  • S. Fiore
    • 1
  • K.-A. Sheppard
    • 1
  1. 1.Hematology Division, Department of MedicineBrigham and Women’s Hospital and Harvard Medical SchoolBostonUSA

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