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Stimulation and Inhibition of Oxygen Radical Formation by Ascorbic Acid and 13-CIS-Retinoic Acid

  • L. J. Marnett
  • V. Samokyszyn
  • D. Laudicina
Chapter
  • 56 Downloads
Part of the Developments in Oncology book series (DION, volume 67)

Abstract

Oxygen radicals are implicated in various stages of carcinogenesis and radical scavengers inhibit tumorigenesis in some models (1–4). However, many presumed radical scavengers exhibit radical generating activity under certain conditions. For example, vitamin C (L-(+)-ascorbic acid) is well known to act as an antioxidant and a prooxidant (5–10). Its antioxidant activity derives from its ability to reduce peroxyl radicals that propagate lipid peroxidation or to reduce the oxidized form (tocopheryl oxyl radical) of the naturally-occuring antioxidant vitamin E (6,7,11). Its prooxidant activity is a result of its ability to reduce metals (especially Fe+3-complexes) to forms that react with O2 to initiate lipid peroxidation (5).

Keywords

Lipid Peroxidation Peroxyl Radical Prooxidant Activity Fatty Acid Hydroperoxide Hydrogen Atom Abstraction 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer Science+Business Media New York 1991

Authors and Affiliations

  • L. J. Marnett
    • 1
  • V. Samokyszyn
    • 1
  • D. Laudicina
    • 1
  1. 1.A.B. Hancock, Jr. Memorial Laboratory for Cancer Research, Departments of Biochemistry and Chemistry, Center in Molecular ToxicologyVanderbilt University School of MedicineNashvilleUSA

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