Localization and Expression of the Eicosanoid Metabolizing P4501VA Gene Family in Rat Tissues and Hepatic Tumors
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The ω-P450 hydroxylase (1VA1-CYP4A) is an eukaryotic gene family(1,2) whose members hydroxylate physiological compounds such as saturated fatty acids, cholesterol, arachidonic acid, leukotrienes and prostaglandins (2,3). Three genes of the rat 1VA gene family have been characterized and shown to be induced by tumor-promoting hypolipidemic drugs (2,3). The physiological function of the ω-oxidized products remains largely undefined. However, the existence of specific P450 isozymes to metabolize these substrates suggests that their induction by tumor promotors may be instrumental in altering the level of autocrine and paracrine mediators of cell growth and differentiation during the development of neoplasia.
KeywordsWestern Immunoblot Analysis Cytochrome P450 Isozyme Hepatocellular Tumor Paracrine Mediator Periportal Region
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