Deficient Lipoxin Formation in Chronic Myelogenous Leukemia

  • J. Å. Lindgren
  • C. Edenius
  • L. Stenke
Part of the Developments in Oncology book series (DION, volume 67)


Recently, we reported formation of lipoxins from endogenous substrate, via platelet-dependent lipoxygenation of granulocyte-derived leukotriene (LT)A4 (1). Furthermore, human platelet suspensions transformed synthetic LTA4 to lipoxins. The platelets also efficiently converted LTA4 to cysteinyl-containing leukotrienes (2).


Arachidonic Acid Chronic Myelogenous Leukemia Elution TIme Chronic Myelogenous Leukemia Patient Platelet Suspension 
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Copyright information

© Springer Science+Business Media New York 1991

Authors and Affiliations

  • J. Å. Lindgren
    • 1
  • C. Edenius
    • 1
  • L. Stenke
    • 1
  1. 1.Department of Physiological ChemistryKarolinska InstitutetSweden

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