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Adding The Finishing Touches: Terminal Elaborations

  • Roslyn M. Bill
  • Leigh Revers
  • Iain B. H. Wilson
Chapter
  • 149 Downloads

Abstract

The remarkable diversity of eukaryotic N- and O-linked oligosaccharide structures is not only a consequence of the branching phenomena we described in Chapters 5 and 6, but can also result from the modification of the non-reducing termini of these branches: that is, the ends of the ‘antennae.’ In fact, it is the terminal groups of these antennae that are the ‘business end’ of major oligosaccharide-ligand interactions, such as those which occur in some intercellular adhesion events, and also between numerous pathogens and their target host cells. Exemplary are the sialic acids which are often part of the ligands for microbial invaders, and also fucosylated structures which are important in determining intraspecies variation and the migrational behaviour of leukocytes.

Keywords

Sialic Acid Blood Group Chinese Hamster Ovary Cell Neural Cell Adhesion Molecule Polysialic Acid 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer Science+Business Media New York 1998

Authors and Affiliations

  • Roslyn M. Bill
    • 1
  • Leigh Revers
    • 2
  • Iain B. H. Wilson
    • 3
  1. 1.The Lundberg LaboratoryUniversity of GöteborgGöteborgSweden
  2. 2.Department of Biochemistry ResearchThe Hospital for Sick ChildrenTorontoCanada
  3. 3.Department of Biochemistry ResearchUniversity of DundeeDundeeScotland

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