Advertisement

Kaposi’s Sarcoma and Other Rare Malignancies in Homosexual Men

  • Yehudi M. Felman
  • David G. Ostrow
  • Terry Alan Sandholzer
Chapter
  • 32 Downloads

Abstract

Kaposi’s sarcoma (KS) is named after the Austrian dermatologist Moritz Kaposi Kohn (1837–1902), who first recognized the disease in 1872.1 Its synonym is multiple idiopathic hemorrhagic sarcoma, and it is described histologically in Robbin’s text on pathology as having four essential diagnostic components:
  1. 1.

    Endothelial proliferations, sometimes as cellular sheets, sometimes as multiple thin-walled new vessel formations.

     
  2. 2.

    Hemorrhage, recent or old, manifested by extravascular red blood cells or hemosiderin.

     
  3. 3.

    Fibroblastic proliferation.

     
  4. 4.

    An inflammatory reaction composed of lymphocytes.

     

Keywords

Acquire Immunodeficiency Syndrome Pneumocystis Carinii Pneumonia Rare Malignancy Butyl Nitrite Cloacogenic Carcinoma 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. 1.
    Kaposi M: Idiopathisches multiples Pigmentsarkom des Haut. Arch Dermatol Syphilol 4: 265–273, 1872.CrossRefGoogle Scholar
  2. 2.
    Urmocher C, Myskowski P, Ochoa M, et al: Outbreak of Kaposi’s sarcoma with cytomegalovirus in young homosexual men. Am J Med 72: 569, 1982.CrossRefGoogle Scholar
  3. 3.
    Klepp O, Dahl O, Stenning JT: Association of Kaposi’s sarcoma with prior immunosuppressive therapy: A 5-year study of Kaposi’s sarcoma in Norway. Cancer 12: 2626–2630, 1978.CrossRefGoogle Scholar
  4. 4.
    Laor Y, Schwartz RA: Epidemiologic aspects of American Kaposi’s sarcoma. J Surg Oncol 12: 299–303, 1979.PubMedCrossRefGoogle Scholar
  5. 5.
    Safai B, Mile V, Geraldo G, et al: Association of Kaposi’s sarcoma with second primary malignancies. Possible etiopathogenic implications. Cancer 45: 1472, 1980.PubMedCrossRefGoogle Scholar
  6. 6.
    Centers for Disease Control: Pneumocystis pneumonia-Los Angeles. MMWR 30: 250–252, 1981.Google Scholar
  7. 7.
    Centers for Disease Control: Kaposi’s sarcoma and Pneumocystis carinii among homosexual men-New York City and California. MMWR 30: 305, 1982.Google Scholar
  8. 8.
    New York City Department of Health: Acquired immunodeficiency syndrome. City Health Information 1: 1–2, 1982.Google Scholar
  9. 9.
    Mathur V, Enlow RW, Spigland I, et al: Generalized lymphadenopathy: A prodrome of Kaposi’s sarcoma in male homosexuals? in Abstracts of the 1982 ICAAC, 1982, p 218.Google Scholar
  10. 10.
    Jaffe H: Epidemiology of acquired immunodeficiency syndrome. Presented at the 1982 ICAAC, Miami, Oct 5, 1982.Google Scholar
  11. 11.
    Centers for Disease Control: Opportunistic infections and Kaposi’s sarcoma among Haitians in the U. S. MMWR 30: 353–361, 1982.Google Scholar
  12. 12.
    Liautand B, Laroche C, Duvivier J, et al: Le sarcome de Kaposi-Estil fréquent en Haiti? Presented at the 18th Congrès des Médecins Francophones de l’Hémisphère Américaine, Port-au-Prince, Haiti, April, 1982.Google Scholar
  13. 13.
    Centers for Disease Control Task Force on Kaposi’s Sarcoma and Opportunistic Infections: Epidemiologic aspects of the current outbreak of Kaposi’s sarcoma and opportunistic infections. N Engl J Med 306: 248–252, 1982.Google Scholar
  14. 14.
    Marmor M, Laubenstein L, William DC, et al: Risk factors for Kaposi’s sarcoma in homosexual men. Lancet 1: 1083–1087, 1982.PubMedCrossRefGoogle Scholar
  15. 15.
    Kornfield H, Vande Stouwe RA, Lange M, et al: T-lymphocyte subpopulations in homosexual men. N Engl J Med 307: 729–731, 1982.CrossRefGoogle Scholar
  16. 16.
    Kalish S, Phair JP, Ostrow DG, et al: Evaluation of homosexuals not responding to hepatitis B vaccine, in Abstracts of the 1982 ICAAC, 1982, p 218.Google Scholar
  17. 17.
    Ammann AJ, Abrams D, Conant M: Acquired immune dysfunction in homosexual men: Immunologic profiles. J Immunology (submitted for publication).Google Scholar
  18. 18.
    Centers for Disease Control: Persistent, generalized lymphadenopathy among homosexual males. MMWR 31: 249, 1982.Google Scholar
  19. 19.
    Kalish SB, Ostrow DG, Phair JP: The spectrum of immunological abnormalities in homosexually active males: Association of laboratory findings with prodromal symptoms of the acquired immunodeficiency syndrome (AIDS) (manuscript in preparation).Google Scholar
  20. 20.
    Wintrobe M: Clinical Hematology, ed 8. New York, Lea and Febiger, 1981, pp 1279–1281.Google Scholar
  21. 21.
    Ostow DG: A glossary of AIDS terms. Homosexual Health Report 1: 10–11, 1983.Google Scholar
  22. 22.
    Centers for Disease Control: Diffuse undifferentiated non-Hodgkin’s lymphoma among homosexual males-United States. MMWR 31: 277, 1982.Google Scholar
  23. 23.
    Cooper HS, Patchefsky AS, Marks G: Cloacogenic carcinoma of the anorectum in homosexual men: An observation of four cases. Dis Colon Rectum 22: 557–558, 1979.PubMedCrossRefGoogle Scholar
  24. 24.
    Li FP, Osborn D, Cronin CM: Anorectal squamous carcinoma in two homosexual men. Lancet 1: 391, 1982.CrossRefGoogle Scholar
  25. 25.
    Minutes of a workshop on AIDS held at the CDC, Atlanta, Georgia, March 3, 1982 (unpublished).Google Scholar
  26. 26.
    Friedman-Kien AE: Disseminated Kaposi’s sarcoma syndrome. J Am Acad Dermatol 5: 471, 1981.Google Scholar
  27. 27.
    Klein G: Herpes viruses and oncogenesis. Proc Natl Acad Sci USA 69: 1056–1064, 1972.PubMedCrossRefGoogle Scholar
  28. 28.
    Donnenberg AD, Bell RB, Aurelian L: Immunity to herpes simplex virus II. I. Development of virus-specific lymphoproliferative and LMIF responses in HSV-2 infected guinea pigs. Cell Immunol 56: 526–539, 1980.PubMedCrossRefGoogle Scholar
  29. 29.
    Drew WL, Conant MA, Miner RC, et al: Cytomegalovirus and Kaposi’s sarcoma in young homosexual men. Lancet 1: 125–127, 1982.CrossRefGoogle Scholar
  30. 30.
    Drew WL, Mintz L, Minet RC, et al: Prevalence of cytomegalovirus in homosexual men. J Infect Dis 143: 188, 1981.PubMedCrossRefGoogle Scholar
  31. 31.
    Ostrow DG: Kaposi’s sarcoma and acquired immunodeficiency syndrome: An overview. Homosexual Health Report 1: 13, 1982.Google Scholar
  32. 32.
    Safai B, Good RA: Kaposi’s sarcoma: A review of recent developments. Clin Bull 10: 62, 1982.Google Scholar
  33. 33.
    Hymes KB, Cheung TL, Greene JB, et al: Kaposi’s sarcoma in homosexual men: A report of 8 cases. Lancet 2: 598, 1981.PubMedCrossRefGoogle Scholar
  34. 34.
    Hardy MA, Goldforb P, Levine S, et al: De novo Kaposi’s sarcoma in renal transplant. Cancer 38: 144–148, 1976.PubMedCrossRefGoogle Scholar
  35. 35.
    Anderson KV: Tumors of the skin, in Rook A, Wilkinson DS, Ebling FJB (eds): Textbook of Dermatology, Oxford, Blackwell, 1972, vol 2, p 1998.Google Scholar
  36. 36.
    Finkbeiner WE, Egbert BM, Groundwater JR, et al: Kaposi’s sarcoma in young homosexual men. A histopathological study with particular reference to lymph node involvement. Arch Pathol Lab Med 106: 261–264, 1982.PubMedGoogle Scholar
  37. 37.
    Epstein DM, Gefter WB, Conrad K, et al: Lung disease in homosexual men. Radiology 143: 7–20, 1982.PubMedGoogle Scholar
  38. 38.
    Rosai J, Sumner HW, Kostianovsky M, et al: Angiocarcinoma of the skin. A clinicopathologic and fine structural study. Hum Pathol 7: 83–109, 1976.PubMedCrossRefGoogle Scholar
  39. 39.
    Domonkos AN: Andrew’s Diseases of the Skin: Clinical Dermatology. Philadelphia, Saunders, 1971, pp 712–716.Google Scholar
  40. 40.
    Schietinger H: Personal communication.Google Scholar

Copyright information

© Plenum Publishing Corporation 1983

Authors and Affiliations

  • Yehudi M. Felman
    • 1
    • 2
    • 3
  • David G. Ostrow
    • 4
    • 5
    • 6
    • 7
  • Terry Alan Sandholzer
    • 8
  1. 1.Department of DermatologyState University of New York Downstate Medical SchoolBrooklynUSA
  2. 2.Department of Preventive MedicineState University of New York Downstate Medical SchoolBrooklynUSA
  3. 3.Department of Community HealthState University of New York Downstate Medical SchoolBrooklynUSA
  4. 4.Biological Psychiatry ProgramLakeside Veterans Administration Medical CenterChicagoUSA
  5. 5.Department of PsychiatryNorthwestern University Medical SchoolChicagoUSA
  6. 6.Department of Community MedicineNorthwestern University Medical SchoolChicagoUSA
  7. 7.Howard Brown Memorial ClinicChicagoUSA
  8. 8.San FranciscoUSA

Personalised recommendations