Guinea Pig Alveolar Macrophages Probably Kill M. Tuberculosis H37Rv and H37Ra In Vivo by Producing Hydrogen Peroxide
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The major phagocytic cell involved in host resistance to Mycobacterium tuberculosis infection is probably the alveolar macrophage. It seems likely that macrophages, at least in the immune animal, can kill M. tuberculosis (1) and this might involve the production of hydrogen peroxide (H2O2) by the macrophages. Macrophages release H2O2 in vitro when exposed to phagocytic stimuli or certain soluble agents that perturb the plasma membrane (8, 9). H2O2 can kill M. tuberculosis and resistance to H2O2 in vitro correlates with high virulence in the guinea pig (11, 5).
KeywordsAlveolar Macrophage Tuberculosis H37Rv Mycobacterium Tuberculosis Infection H202 Release Royal Postgraduate Medical School
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