Macrophage Oxygen-Dependent Killing of Intracellular Parasites: Toxoplasma and Leishmania

  • Henry W. Murray
Conference paper
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 162)


The importance of cell-mediated immunity in host resistance to infection caused by intracellular pathogens has been well-established. Similarly, it has been known for some time that monocytes and macrophages play primary roles in the efferent limb of the cellular response to such infections (1–9). The mechanisms by which these phagocytes exert antimicrobial activity, however, have been largely unexplored. During the past several years, work in this and other laboratories has indicated that the generation of toxic oxygen intermediates contributes importantly to the ability of mononuclear phagocytes to kill or inhibit the growth of ingested microbial pathogens (10–20). Thus, considerable evidence is now available to suggest that the well-recognized oxygen-dependent mechanism present in polymorphonuclear leukocytes, which generates a number of toxic products including superoxide anion (O 2 - ), hydrogen peroxide (H2O2), and hydroxyl radical (OH) (21–23), is also present and operative in monocytes and macrophages.


Phorbol Myristate Acetate Oxidative Burst Respiratory Burst Activity Proteose Peptone Antiprotozoal Activity 
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  1. 1.
    Mackaness, G.B. (1962). J. Exp. Med. 116:381.PubMedCrossRefGoogle Scholar
  2. 2.
    North, R.J. (1970). J. Exp. Med. 132:535.PubMedCrossRefGoogle Scholar
  3. 3.
    McLoed, R. and Remington, J.S. (1977). Cell Immunol. 34:156.CrossRefGoogle Scholar
  4. 4.
    North, R.J. (1978). J. Immunol. 121:806.PubMedGoogle Scholar
  5. 5.
    Jones, T.C., Len, L. and Hirsch, J.G. (1975). J. Exp. Med. 141:466.PubMedCrossRefGoogle Scholar
  6. 6.
    Mauel, J., Buchmuller, Y. and Beelin, R. (1978). J. Exp. Med. 148:393.PubMedCrossRefGoogle Scholar
  7. 7.
    Nogueira, N. and Cohn, Z.A. (1978). J. Exp. Med. 148:288.PubMedCrossRefGoogle Scholar
  8. 8.
    Nacy, C.A. and Meltzer, M.S. (1979). J. Immunol. 123:2544.PubMedGoogle Scholar
  9. 9.
    Nathan, C.F., Murray, H.W. and Cohn, Z.A. (1980). N. Engl. J. Med. 303:622.PubMedCrossRefGoogle Scholar
  10. 10.
    Murray, H.W. and Cohn, Z.A. (1979). J. Exp. Med. 150:938.PubMedCrossRefGoogle Scholar
  11. 11.
    Murray, H.W., Juangbhanich, C.W., Nathan, C.F. and Cohn, Z.A., (1979). J. Exp. Med. 150:950.PubMedCrossRefGoogle Scholar
  12. 12.
    Murray, H.W. and Cohn, Z.A. (1980). J. Exp. Med. 152:1596.PubMedCrossRefGoogle Scholar
  13. 13.
    Murray, H.W., Nathan, C.F. and Cohn, Z.A. (1980). J. Exp. Med. 152:1601.Google Scholar
  14. 14.
    Murray, H.W. (1981). J. Exp. Med. 153:1302.PubMedCrossRefGoogle Scholar
  15. 15.
    Murray, H.W. (1981). J. Exp. Med. 153:1690.PubMedCrossRefGoogle Scholar
  16. 16.
    Nathan, C.F., Nogueira, N., Juangbhanich, C., Ellis, J., and Cohn, Z.A. (1979). J. Exp. Med. 149:1056.PubMedCrossRefGoogle Scholar
  17. 17.
    Wilson, C.B., Tsai, V., and Remington, J.S. (1980). J. Exp. Med. 151:328.PubMedCrossRefGoogle Scholar
  18. 18.
    Sasada, M. and Johnston, R.B. (1982). J. Exp. Med. 152:85.CrossRefGoogle Scholar
  19. 19.
    Sagone, A.L., King, G.W. and Metz, E.N. (1976). J. Clin. Invest. 57:1352.PubMedCrossRefGoogle Scholar
  20. 20.
    Klebanoff, S.J. and Hamon, C.B. (1975). In Mononuclear Phagocytes in Immunity, Infection, and Pathology, Blackwell Scientific Publications, Oxford, p. 507.Google Scholar
  21. 21.
    Klebanoff, S.J. (1975). Semin. Hematol. 12:117.PubMedGoogle Scholar
  22. 22.
    Babior, B.M. (1978). N. Engl. J. Med. 298:659.PubMedCrossRefGoogle Scholar
  23. 23.
    Badwey, J.A. and Karnovsky, M.L. (1980). Ann. Rev. Biochem. 49:695.PubMedCrossRefGoogle Scholar
  24. 24.
    Berman, J.D., Dwyer, D.M. and Wyler, D.J. (1979), Infect. Immun. 26:375.PubMedGoogle Scholar
  25. 25.
    Rosen, H. and Klebanoff, S.J. (1979). J. Exp. Med. 149:27.PubMedCrossRefGoogle Scholar
  26. 26.
    Nathan, C.F. and Root, R.K. (1977). J. Exp. Med. 146:1648.PubMedCrossRefGoogle Scholar
  27. 27.
    Johnston, R.B., Godzik, C.A. and Cohn, Z.A. (1978). J. Exp. Med. 148:115.PubMedCrossRefGoogle Scholar
  28. 28.
    Baehner, R.L., Boxer, L.A. and Davis, J. (1976). Blood. 48:309.PubMedGoogle Scholar
  29. 29.
    Nathan, C.F., Silverstein, S.C., Brukner, L.H. and Cohn, Z.A. (1979) J. Exp. Med. 149:100.PubMedCrossRefGoogle Scholar
  30. 30.
    Murray, H.W. (1981). Manuscript submitted.Google Scholar
  31. 31.
    Baehner, R.L., Johnston, R.B. and Nathan, D.G. (1972). J. Reticulendothel Soc. 12:150.Google Scholar

Copyright information

© Plenum Press, New York 1983

Authors and Affiliations

  • Henry W. Murray
    • 1
  1. 1.Cornell University Medical CollegeNew YorkUSA

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