Immunologic Lesions During Toxoplasma Gondii Infection

  • Edmond A. Goidl
  • Urban Ramstedt
  • Thomas C. Jones
Conference paper
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 162)


One mechanism of successful parasitism may be the induction of relatively localized, but non-specific, lesions in the mammalian host’s immune response. To investigate this, we have initiated studies of the responses in mice to various antigens during Toxoplasma gondii infection. Experiments reported here indicate that different responses to thymic-independent (TI) and thymic-dependent (TD) antigenic challenges are seen which are consistent with an immunologic lesion or lesions in thymus regulatory pathways. The possibility is raised that the immunologic injury may be an important correlate of microbial infectivity.


Infected Animal Antigenic Challenge Mycobacterium Bovis Primary Immune Response Toxoplasma Infect 
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Copyright information

© Plenum Press, New York 1983

Authors and Affiliations

  • Edmond A. Goidl
    • 1
    • 2
  • Urban Ramstedt
    • 1
    • 2
  • Thomas C. Jones
    • 1
    • 2
  1. 1.Divisions of Allergy and Immunology and International Medicine, Department of Medicine, Medical CollegeCornell UniversityNew YorkUSA
  2. 2.Department of Immunology, Biomedicum CentrumUniversity of UppsalaUppsalaSweden

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