Immunodepression in BALB/c Mice Infected with Leishmania Tropica

  • Phillip A. Scott
  • Jay P. Farrell
Conference paper
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 162)


Leishmania tropica is an obligate intracellular parasite of macrophages which causes cutaneous leishmaniasis in man. Infections in BALB/c mice with this parasite are characterized by the development of large primary ulcers and multiple non-healing metastatic cutaneous lesions (1,2,3). To date, the immunological mechanisms responsible for the inability of BALB/c mice to resolve leishmanial infections are unknown; however, specific suppressor T cells responsible for regulating skin test responses to leishmanial antigens have been reported (3,4). In addition, BALB/c mice infected with L. tropica develop a non-specific immunodepression, as described in this report. This immunodepression is mediated by an adherent suppressor cell which suppresses mitogen and leishmanial antigen responses in a lymphocyte transformation assay.


Spleen Cell Infected Mouse Suppressor Cell Cutaneous Leishmaniasis Stimulation Index 
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Copyright information

© Plenum Press, New York 1983

Authors and Affiliations

  • Phillip A. Scott
    • 1
  • Jay P. Farrell
    • 1
  1. 1.Department of PathobiologyUniversity of PennsylvaniaPhiladelphiaUSA

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