Host Response to Infection with Mycobacterium Bovis (BCG) in Mice: Genetic Study of Natural Resistance

  • Philippe Gros
  • Emil Skamene
  • Adrien Forget
  • Ben Taylor
Conference paper
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 162)


Resistance of mice to several infectious agents has recently been shown to be under simple genetic control (reviewed in 1). Genetic differences in the response of outbred and inbred mice to infection with mycobacteria such as Mycobacterium tuberculosis, Mycobacterium bovis and Mycobacterium lepraemurium have been noted for many years (2,3). We have recently reported that clear segregation of resistance and susceptibility to Mycobacterium bovis (BCG), exists among mice of inbred strains infected with a single intravenous dose of this bacillus (4). The present study deals with detailed genetic analysis of the trait of BCG resistance.


Inbred Strain Natural Resistance Mycobacterium Bovis Strain Distribution Pattern Sensitive Allele 
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  1. 1.
    Genetic Control of Natural Resistance to Infection and Malignancy. Edited by Skamene, E., Kongshavn, P.A.L. and Landy, M. Academic Press, New York, 1980.Google Scholar
  2. 2.
    Gray, D.F., Graham-Smith, P. and Noble, J.L. (1960). J. Hyg. Camb. 58:215.PubMedCrossRefGoogle Scholar
  3. 3.
    Lefford, M.J., Patel, P.J., Poulter, L.N. and Mackaness, G.B. (1977). Infect. Immun. 18 (3):654.PubMedGoogle Scholar
  4. 4.
    Forget, A., Skamene, E., Gros, P., Miailhe, A.C. and Turcotte, R. (1981). Infect. Immun. 32:42.PubMedGoogle Scholar
  5. 5.
    O’Brien, A.D., Rosenstreich, D.L. and Taylor, B.A. (1980). Nature. 287:440.PubMedCrossRefGoogle Scholar
  6. 6.
    Bradley, D.J. and Kirkley, J. (1977). Clin. Exp. Immunol. 30:119.PubMedGoogle Scholar
  7. 7.
    Hormaeche, C.E. (1979). Immunology 37:111.Google Scholar
  8. 8.
    Bradley, D.J. (1979). Acta. Tropica. 36:171.PubMedGoogle Scholar
  9. 9.
    Hormaeche, C.E. (1980). Immunology 41:973.PubMedGoogle Scholar

Copyright information

© Plenum Press, New York 1983

Authors and Affiliations

  • Philippe Gros
    • 1
  • Emil Skamene
    • 1
  • Adrien Forget
    • 2
  • Ben Taylor
    • 3
  1. 1.Montreal General Hospital Research InstituteMontrealCanada
  2. 2.University of MontrealMontrealCanada
  3. 3.Jackson LaboratoriesBar HarborUSA

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