Strain Dependent Variation of Delayed-Type Hypersensitivity in Salmonella Typhimurium Infected Mice

  • Loran Killar
  • Toby K. Eisenstein
Conference paper
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 162)


Development of delayed-type hypersensitivity (DTH) in Salmonella infection was reported as early as 1923, when Zinsser showed that guinea pigs injected with live typhoid bacilli became skin test positive to typhoid antigen (1). A close relationship between DTH and immunity to Salmonella infection was demonstrated in mice by Collins and Mackaness (2). They showed that mice immunized with live Salmonella developed DTH as measured by an increase in footpad thickness 24 hours after injection of a culture supernatant antigen. The appearance of footpad responsiveness correlated with the onset of immunity to challenge with virulent Salmonella (2).


Footpad Thickness Walter Reed Army Institute Hind Footpad Footpad Response aroA Gene 
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  1. 1.
    Zinsser, H. and J.T. Parker. (1923). J. Exp. Med., 37:275.PubMedCrossRefGoogle Scholar
  2. 2.
    Collins, F.M. and G.B. Mackaness. (1968). J. Immunology, 101:830.Google Scholar
  3. 3.
    Eisenstein, T.K., L. Deakins, L. Killar, P. Saluk, and B. Sultzer. (1982). Infect. and Immunity, 36:696.Google Scholar
  4. 4.
    Hoiseth, S.K. and B.A.D. Stocker (1981). Nature, 291:238.PubMedCrossRefGoogle Scholar
  5. 5.
    Lowry, O.H., N.J. Rosebrough, A.L. Farr and R.J. Randall (1951). J. Biol. Chem. 193:265.PubMedGoogle Scholar
  6. 6.
    Bliss, C.J. (1967). Statistics in Biology, vol. 3, McGraw-Hill, New York, p. 63–65.Google Scholar
  7. 7.
    Plant, J. and A.A. Glynn (1974). Nature, 248:345.PubMedCrossRefGoogle Scholar
  8. 8.
    Hormaeche, C.E., MC. Fahrenkrog, R.A. Pettifor and J. Brock (1981). Immunology, 43:547.PubMedGoogle Scholar

Copyright information

© Plenum Press, New York 1983

Authors and Affiliations

  • Loran Killar
    • 1
  • Toby K. Eisenstein
    • 1
  1. 1.Department of Microbiology and ImmunologyTemple University School of MedicinePhiladelphiaUSA

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