Natural and Acquired Resistance to Trypanosoma Cruzi

  • Thomas M. Trischmann
Conference paper
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 162)


Since the identification in 1909 of Trypanosoma cruzi as the causative agent of Chagas’ disease, a large body of literature has arisen relating to the nature of the disease. Two observations in particular initially stimulated my interest in the immunology of Chagas’ disease. The first was that the severity of the disease that occurs following the initial infection with T. cruzi (called the acute stage of the disease) can range from asymptomatic to lethal (1). This variation in what can be termed natural resistance may be the result of multiple genetic and environmental factors, but it is easy to imagine how differences in the immune responses made by individuals could be critical for influencing the ensuing course of the disease.


Bone Marrow Cell Recombinant Inbred Trypanosoma Cruzi Congenic Strain Natural Resistance 
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  1. 1.
    Segovia, S.A., et al. (1974). Bull. WHO, 50:459.Google Scholar
  2. 2.
    Teixeira, A.R.L. (1977). In “Immunity to Blood Parasites of-Animals and Man” (L. Miller, J. Pino, and J. McKelvey, eds.), p. 243. Plenum, New York.Google Scholar
  3. 3.
    Pizzi, T., Agosin, M., Christen, R., Hoecker, G., and Neghme, A. (1949). Boletin Informaciones Parasitarias Chilenas, 4:48.Google Scholar
  4. 4.
    Seah, S., and Marsden, P.D. (1969). Ann Trop. Med. Parasitol., 63:211.Google Scholar
  5. 5.
    Hauschka, T.S., Goodwin, M.B., Palmquist, J. and Brown, E. (1950). Am. J. Trop. Med., 30:1.Google Scholar
  6. 6.
    Trischmann, T., Tanowitz, H., Wittner, M. and Bloom, B. (1978). Exp. Parasitol., 45:160.PubMedCrossRefGoogle Scholar
  7. 7.
    Hanson, W.L., and Roberson, E.L. (1974). J. Protozool., 21:512.PubMedGoogle Scholar
  8. 8.
    Hanson, W.L. (1977). In “Chagas’ Disease”. Pan American Health Organization.Scientific publication No. 347, p. 22.Google Scholar
  9. 9.
    Hauschka, T.S. (1947). J. Parasitol. 33:399.PubMedCrossRefGoogle Scholar
  10. 10.
    Culbertson, J.T., and Kessler, W.R. (1942). J. Parasitol., 28:155.CrossRefGoogle Scholar
  11. 11.
    Blackwell, J., Freeman, J., and Bradley, D. (1980). Nature, 283:72.PubMedCrossRefGoogle Scholar
  12. 12.
    Williams, D.M., Grumet, F.C., and Remington, J. S. (1978). Infect. Immun., 19:416.PubMedGoogle Scholar
  13. 13.
    Taylor, B.A., Bailey, D.W., Cherry, M., Riblet, R., and Weigert, M. (1975). Nature, 256:644.PubMedCrossRefGoogle Scholar
  14. 14.
    Howard, J.G., Hale, C., and Liew, F.Y. (1980), Nature, 288:161.PubMedCrossRefGoogle Scholar
  15. 15.
    Hormaeche, C.E. (1979). Immunology, 37:319.PubMedGoogle Scholar
  16. 16.
    Budzko, D.B., Pizzimenti, M.C., and Kierszenbaum, F. (1975). Infect. Immun., 11:86.PubMedGoogle Scholar
  17. 17.
    Lopez, A.F., Bunn Moreno, M.M., and Sanderson, C.J. (1978). Int. J. Parasitol., 8:485.PubMedCrossRefGoogle Scholar
  18. 18.
    Hoff, R. (1975). J. Exp. Med., 142:299.PubMedCrossRefGoogle Scholar
  19. 19.
    Kuhn, R.E., and Murnane, J.E. (1977). Exp. Parasitol., 41:66.PubMedCrossRefGoogle Scholar
  20. 20.
    Trischmann, T.M., and Bloom, B.R. (1980). Exp. Parasitol., 49:225.PubMedCrossRefGoogle Scholar
  21. 21.
    Brener, Z. (1980). Adv. Parasitol., 18:247.PubMedCrossRefGoogle Scholar
  22. 22.
    Kierszenbaum, F. (1980). J. Parasitol. 66:673.PubMedCrossRefGoogle Scholar
  23. 23.
    Gordon, J. (1979). J. Immunol. Meth. 25:277.CrossRefGoogle Scholar
  24. 24.
    McHardy, N. (1978). Trans. R. Soc. Trop. Med, Hyg., 72:201.CrossRefGoogle Scholar
  25. 25.
    Ribeiro Dos Santos, R., and Hudson, L. (1980). Parasite Immunol., 2:1.CrossRefGoogle Scholar
  26. 26.
    Abrahamsohn, I.A., and Kloetzel, J.K. (1980), Parasitology, 80:147.PubMedCrossRefGoogle Scholar
  27. 27.
    Nogueira, N., Chaplan, S. and Cohn, Z. (1980). J. Exp. Med., 152:447.PubMedCrossRefGoogle Scholar
  28. 28.
    Santos-Buch, C.A., and Teixeira, A.R.L. (1974), J. Exp. Med., 140:38.PubMedCrossRefGoogle Scholar

Copyright information

© Plenum Press, New York 1983

Authors and Affiliations

  • Thomas M. Trischmann
    • 1
  1. 1.Tropical Medicine CenterThe Johns Hopkins University School of Hygiene and Public HealthBaltimoreUSA

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