Intracellular Destruction of Leishmania Tropica by Macrophages Activated in Vivo with Mycobacterium Bovis Strain BCG

  • Michael G. Pappas
  • Charles N. Oster
  • Carol A. Nacy
Conference paper
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 162)


Leishmania tropica, an intracellular protozoan parasite, infects and replicates in macrophages of C3H/HeN and C3H/HeJ mice in vitro (1). Exposure of resident peritoneal macrophages to amastigotes for 1 hr results in 20–25% infected macrophages, Intracellular parasites increase from 1.7 to >3.5 per macrophage over 72 hr.


Infected Macrophage Intracellular Parasite Mycobacterium BOVIS Microbicidal Activity Intracellular Killing 
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Copyright information

© Plenum Press, New York 1983

Authors and Affiliations

  • Michael G. Pappas
    • 1
  • Charles N. Oster
    • 1
  • Carol A. Nacy
    • 1
  1. 1.Department of ImmunologyWalter Reed Army Institute of ResearchUSA

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