Immunological Comparison of Ocular Disease Induced by two Strains of Herpes Virus of Different Virulence
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In previous reports (4,5) we discussed the immunopotentiating or immunosuppressive role of adherent cells from regional draining lymph nodes and spleen during the course of experimental Herpes simplex virus (HSV) keratitis induced by the highly virulent H-4 strain of HSV. Further, we reported that carrageenan sensitive cells (macrophages) induced differential effects in lymphocyte responsiveness to the mitogens phytohaemagglutinin (PHA), con-canavalin A (Con A) and pokeweed (PWM), as well as to specific HSV antigens. In a variety of disease states, modulation of immune function by macrophages has been attributed to prostaglandins. The evidence implicating prostaglandins in immune regulation is based on the ability of a prostaglandin synthetase inhibitor, Indomethacin, to enhance the mitogenic response of lectin stimulated lymphocytes.
KeywordsHerpes Simplex Virus Ocular Disease Splenic Lymphocyte Ocular Infection Infected Rabbit
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