Pharmacodynamics of 5-Fluorouracil and Leucovorin
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Fluoropyrimidine therapy is a corner-stone of chemotherapeutic management of metastatic cancer. Although only about 15% of patients respond to initial single-agent FUra therapy, a greater number may have disease stabilization with comparatively mild toxicity1,2. Fifteen years ago, we reported that continuous intraportal infusion of Fyra in a significant prolonged survival compared to historical controls3. Since then, significant discoveries of the mechanisms of action of FUra and attempts at rational approaches in its application have been made.
KeywordsFolinic Acid Group FUra Murine Colon Adenocarcinoma Fluoropyrimidine Therapy Chemotherapeutic Management
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