Clinical Experience with 5-FU/DDP ± OHDW Combination Chemotherapy in Patients with Advanced Colorectal Carcinoma

  • Stefan Madajewicz
  • John J. Fiore
  • Mohammad H. Zarrabi
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 244)


Many avenues are being explored in an effort to develop more effective and selective treatment of patients with advanced colorectal carcinoma. One approach termed biochemical modulation is based on “immortal”, although minimal, 5-fluorouracil (5-FU) activity. At least six types of modulation have been attempted based on the current understating of 5-FU metabolism: 1) Methotrexate, 2) Thymidine, 3) PALA, 4) Allopurinol, 5) Folinic acid (FA), and 6) cisPlatin (DDP).


Lung Metastasis Folinic Acid Advanced Colorectal Cancer Methionine Metabolism Biochemical Modulation 
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Copyright information

© Plenum Press, New York 1988

Authors and Affiliations

  • Stefan Madajewicz
    • 1
  • John J. Fiore
    • 1
  • Mohammad H. Zarrabi
    • 1
  1. 1.Division of Oncology, Health Sciences CenterState University of New York at Stony BrookStony BrookUSA

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