Clinical Investigation of Lithium Therapy in Acute Leukemia

  • Dominique J. Charron
  • Thierry Schmitt
  • Laurent Degos
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 127)


It has been known for a long time that patients receiving lithium carbonate (Li2CO3 for manic-depressive psychosis develop a significant polymorphonuclear leukocytosis (Bille and Plum, 1955; Shopsin et al., 1971). Moreover, in vitro studies have demonstrated a stimulatory effect of Li2CO3 on granulopoiesis (Tisman et al., 1973; Harker et al., 1975) and have suggested that Li2CO3 acts either by increasing colony stimulating factor (CSF) production by mononuclear cells (Harker et al., 1977) or potentiating the action of CSF (Morley and Galbraith, 1978). The exact mechanism has yet to be clarified by extended in vivo and in vitro studies, although the present data support the evidence for a multilevel action.


Acute Lymphoblastic Leukemia Aplastic Anemia Acute Leukemia Disseminate Intravascular Coagulation Hairy Cell Leukemia 
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Copyright information

© Plenum Press, New York 1980

Authors and Affiliations

  • Dominique J. Charron
    • 1
  • Thierry Schmitt
    • 1
  • Laurent Degos
    • 1
  1. 1.Institut de Recherche sur les Maladies du SangHopital Saint-LouisParisFrance

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