Stimulation of Granulopoiesis in vitro and in vivo Using Lithium in Children with Chronic Neutropenia

  • Helen S. L. Chan
  • Melvin H. Freedman
  • E. Fred Saunders
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 127)


Psychiatric patients have been observed to have a dramatic increase in their neutrophil counts while on lithium (Li) therapy (Mayfield and Brown, 1966). There are reports of the ability of lithium to improve chemotherapy-induced neutropenia in cancer patients (Greco et al., 1976; Stein et al., 1977) and in Felty’s syndrome (Gupta et al., 1975). Lithium appears to act through a direct stimulation of committed granulocytic progenitors (CFU-c) (Tisman et al., 1973; Morley and Galbraith, 1978) as well as an increase of colony-stimulating activity (CSA), the humoral stimulator of granulopoiesis (Harker et al., 1977; Gupta et al., 1976). Our purpose was to study and correlate the in vitro and in vivo effect of lithium on granulopoiesis in children with chronic neutropenia.


Aplastic Anemia Lithium Therapy Stem Cell Compartment Exocrine Pancreatic Insufficiency Severe Congenital Neutropenia 
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Copyright information

© Plenum Press, New York 1980

Authors and Affiliations

  • Helen S. L. Chan
    • 1
  • Melvin H. Freedman
    • 1
  • E. Fred Saunders
    • 1
  1. 1.Division of Hematology Hospital for Sick Children and the Department of PediatricsUniversity of TorontoTorontoCanada

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