Myelopoietic Modulation by Lithium: in vitro Experiments on its Mechanisms of Action in Man

  • Dharmvir S. Verma
  • Gary Spitzer
  • Axel R. Zander
  • Miloslav A. Beran
  • Karel A. Dicke
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 127)


Various reports have described consistent elevation of granulocytes accompanying lithium administratioin in psychiatric patients (Mayfield and Brown, 1966; O’Connell, 1970; Shopsin et al., 1971). in 1975 Gupta et al. reported that lithium increased the leukocyte count in patients with Felty’s syndrome. They also documented increase in colony stimulating activity (CSA) active against murine bone marrow cells in the urine of these patients (Gupta et al., 1976). Recently, several authors have reported that lithium, when administered to patients with various malignancies, may ameliorate chemotherapy induced myelosuppression (Catane et al., 1976; Greco et al., 1976; Stein et al., 1977; Tisman, 1974; Tisman and Wu, 1977) and reduce the duration of granulocytopenia induced by chemotherapy in acute myeloid leukemia (Charron et al., 1977). Lithium has also been used to elevate leukocytes, platelets and hemoglobin levels in aplastic anemia with some success (Barrett et al., 1977).


Acute Myeloid Leukemia Conditioned Medium Colony Formation Adherent Cell Aplastic Anemia 
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Copyright information

© Plenum Press, New York 1980

Authors and Affiliations

  • Dharmvir S. Verma
    • 1
  • Gary Spitzer
    • 1
  • Axel R. Zander
    • 1
  • Miloslav A. Beran
    • 1
  • Karel A. Dicke
    • 1
  1. 1.Department of Developmental TherapeuticsThe University of Texas System Cancer Center M.D. Anderson Hospital and Tumor InstituteHoustonUSA

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