Molecular Pathogenesis of Campylobacter jejuni Enteritis

  • Michael E. Konkel
  • Witold CieplakJr.
Part of the Infectious Agents and Pathogenesis book series (IAPA)


Campylobacter jejuni and Campylobacter coli are now recognized as among the most prevalent causes of bacterial enteritis in both developed and developing countries. Infection rates with C. jejuni in the United States and Great Britain have been estimated at 10 per 1000 population, thus equaling and likely surpassing the rates of Salmonella infection.(1) In addition to causing acute enterocolitis, C. jejuni infection has recently been implicated as a frequent antecedent to the development of Guillain-Barré-type polyneuropathy.(2,3) Despite the recognition of Campylobacter spp. as an important etiologic agent of enteritis, the biologic and molecular pathogenic aspects of Campylobacter enteritis remain ill-defined. There is considerable disagreement whether C. jejuni, like more well-recognized enteropathogens (e.g., Shigella, Escherichia coli, Vibrio cholerae, and Yersinia), produce any readily identifiable pathogenic/virulence determinants such as cytotoxins, entero-toxins, and invasion-related molecules during cultivation in vitro. Enteritis caused by C. jejuni and related species may represent an example of the interactions that occur between pathogens and the host environment and result in the expression of virulence determinants during the pathogenesis of disease.(4) This review summarizes the microbiology and immunology of C. jejuni and concentrates on the available knowledge concerning the molecular bases of disease causation by this organism.


Cholera Toxin Outer Membrane Protein Molecular Pathogenesis Human Epithelial Cell Epithelial Cell Culture 
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Copyright information

© Springer Science+Business Media New York 1996

Authors and Affiliations

  • Michael E. Konkel
    • 1
  • Witold CieplakJr.
    • 2
  1. 1.Department of MicrobiologyWashington State UniversityPullmanUSA
  2. 2.Laboratory of Intracellular Parasites, Rocky Mountain Laboratories, National Institute of Allergy and Infectious DiseasesNational Institutes of HealthHamiltonUSA

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