Goodness-of-fit Tests for Correlated Bilateral Data from Multiple Groups

  • Xiaobin Liu
  • Chang-Xing MaEmail author


Correlated bilateral data often arise in ophthalmological and otolaryngological studies, where responses of paired body parts of each subject are measured. A number of statistical methods have been proposed to tackle this intra-class correlation problem, and in practice it is important to choose the most suitable one which fits the observed data well. Tang et al. (Stat Methods Med Res 21(4):331–345, 2012, [16]) compared different goodness-of-fit statistics for correlated data including only two groups. In this article, we investigate the general situation for \(g\ge 2\) groups. Our simulation results show that the performance of the goodness-of-fit test methods, as measured by the power and the type I error rate, is model depending. The observed performance difference is more significant in scenario with small sample size and/or highly dependent data structure. Examples from ophthalmologic studies are used to illustrate the application of these goodness-of-fit test methods.


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© Springer Nature Switzerland AG 2020

Authors and Affiliations

  1. 1.Department of BiostatisticsUniversity at BuffaloBuffaloUSA

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