Activity of macrolides against mycobacteria

  • Lowell S. Young
  • Luiz E. Bermudez
Part of the Milestones in Drug Therapy MDT book series (MDT)


The description of human disease caused by mycobacterial pathogens dates back to Biblical times. Presently, mycobacterial diseases account for a large proportion of all serious infectious disorders observed worldwide. Estimates of the numbers of leprosy cases exceed 20 million. Tuberculosis in all of its forms is believed to be the most common of the fatal infections, with total annual mortality figures of three million adult deaths of adults in developing countries (malaria may be numerically even more common but kills fewer patients) [1]. Tuberculosis is a re-emergent problem in many industrialized countries. In the modern world of global interdependency, rapid transportation, expanding trade, and migration, tuberculosis in any country is a threat to people of every country. The current global reemergence of tuberculosis can be attributed to several factors, among them, the HIVepidemic, social dislocation, poverty, overcrowding, and inadequate investment in public-health measures.


Antimicrob Agent Mycobacterium Avium Mycobacterium Avium Complex Lepromatous Leprosy Beige Mouse 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Springer Basel AG 2002

Authors and Affiliations

  • Lowell S. Young
    • 1
  • Luiz E. Bermudez
    • 1
  1. 1.Kuzell Institute for Arthritis and Infectious DiseasesCalifornia Pacific Medical Center Research InstituteSan FranciscoUSA

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