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Polyketide diversity

  • Leonard Katz
Chapter
Part of the Milestones in Drug Therapy MDT book series (MDT)

Abstract

Polyketides are natural products made by bacteria, fungi and plants, that have gained widespread use in human medicine (antibacterials, antifungals, anticancers, immunosuppressants), veterinary medicine (anthelmintics), and agriculture (insecticides). The term was coined by Collie in 1907 to describe compounds that were composed of units containing multiple “ketide” (-CH2-CO-) groups which, as building blocks, either could persist in the final structure or be modified during their biosynthesis [1]. The modification of either carbon center of the ketide unit is the basis for the large and structurally diverse array of compounds that are classified as polyketides.

Keywords

Extender Unit Methyl Side Chain Polyketide Chain Polyketide Synthesis Acyl Carrier Protein Domain 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer Basel AG 2002

Authors and Affiliations

  • Leonard Katz
    • 1
  1. 1.Kosan Biosciences Inc.HaywardUSA

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