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Raman Spectroscopy in Skin Research and Dermal Drug Delivery

  • Nathalie Jung
  • Branko Vukosavljevic
  • Maike WindbergsEmail author
Chapter
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Part of the Springer Series in Surface Sciences book series (SSSUR, volume 66)

Abstract

Raman spectroscopy represents an upcoming analytical technique in the field of skin research and dermal drug delivery. In the last few decades, significant progress in optical equipment like lasers and detectors as well as in microscopy and software development paved the way for chemically selective three-dimensional Raman imaging with high spatial resolution. Potential applications range from analysis of physiological and pathophysiological skin conditions (e.g. non-destructive cancer detection in clinics) up to surgery guidance. In the field of drug delivery and cosmetics , Raman microscopy is successfully applied for investigating interactions with skin as well as for elucidation of drug penetration kinetics within the different skin tissue layers, thus strongly supporting rational development and improving product safety of novel skin therapeutics. This chapter provides a brief introduction about skin anatomy and dermal drug delivery systems, as well as state-of-the-art analytics in skin research. Furthermore, the potential of Raman spectroscopy for application in skin research, particularly its advantages and limitations in the field, is comprehensively elaborated. Subsequently, an overview about skin research studies applying Raman spectroscopy is given comprising various in vitro as well as in vivo implementations. Finally, employment of Raman spectroscopy for advanced diagnosis and surgery guidance are discussed and a future perspective in the field of skin research is given.

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Copyright information

© Springer International Publishing AG 2018

Authors and Affiliations

  • Nathalie Jung
    • 1
    • 2
  • Branko Vukosavljevic
    • 1
  • Maike Windbergs
    • 1
    • 2
    Email author
  1. 1.Institute of Pharmaceutical Technology and Buchmann Institute for Molecular Life SciencesGoethe UniversityFrankfurt am MainGermany
  2. 2.Department of Drug DeliveryHelmholtz Centre for Infection Research (HZI) and Helmholtz Institute for Pharmaceutical Research Saarland (HIPS)SaarbrueckenGermany

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