Locally Advanced, Locally Recurrent, and Metastatic Breast Cancer

  • G. Fleming


Two tumor markers are approved by the Food and Drug Administration for the early detection of recurrent disease in breast cancer patients who have stage II and III disease: CA27.29 and CA15-3. The marketed assays use antibodies which recognize similar but not equivalent epitopes on a mucin-like membrane glycoprotein (the product of the MUC-1 gene), which is shed from tumor cells into the serum. These tests are not suitable for screening, as they are rarely positive in early-stage disease. CA27.29, which has been suggested to be more sensitive than CA15-3, is elevated in only 29% of woman with stage I disease, 36 % of women with stage II disease, and 59% of women with stage III disease. CA15-3 and CA27.29 may also be elevated in other malignancies, such as ovarian or pancreatic cancer, as well in as patients with benign conditions, particularly kidney and liver disease.


Breast Cancer Clin Oncol Metastatic Breast Cancer Advanced Breast Cancer Radiat Oncol Biol Phys 
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© Springer-Verlag Berlin Heidelberg 2003

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  • G. Fleming

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