• Host defenses are occasionally incapable of combating the introduction of microbes and establishment of infection, particularly when a large number of microbes are present or host defenses are diminished, or when an ongoing source of microbial contamination exists. • Source control consists of: a) reduction or eradication of the primary source of microbial inoculation or established infection, and b) prevention of the ongoing introduction of microbes. • Inadequate source control increases morbidity and mortality as much as seven fold
KeywordsHost Defense Source Control Fibrin Clot Biological Rationale Intraabdominal Infection
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