Opioids pp 241-277 | Cite as

Chemistry of Nonpeptide Opioids

  • S. Archer
Part of the Handbook of Experimental Pharmacology book series (HEP, volume 104 / 1)


During the past three decades interest in nonpeptide opioids has been rekindled in part by the introduction of a clinically acceptable analgesic of the mixed agoinst-antagonist type with reduced addiction liability (Archer et al. 1962), which was followed by the seminal papers by Martin (Martin 1967; Martin et al. 1976) on multiple opioid receptors. The next several years were marked by the development of more analgesics of the mixed agonist-antagonist class, pure narcotic antagonists devoid of agonist action, and the discovery of higher potent opioids in the oripavine, fentanyl, and meperidine series. On a parallel front the past few decades were marked by the introduction of a methadone maintenance program for narcotic addicts (Dole and Nyswander 1965); and the realization that heroin abusers are particularly susceptible to AIDS has stimulated research on new modalities for treating opiate addicts.


Total Synthesis Lithium Aluminum Hydride Narcotic Antagonist Methyl Propiolate Propionic Anhydride 
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